If vitamins are so bad why is FDA giving them to PhRMA

Update: April 2011 - CDC: Half of US adults take vitamins, supplements

By MIKE STOBBE, AP Medical WriterWed Apr 13, 1:50 pm ET

ATLANTA – About half of U.S. adults take vitamins and other dietary supplements — a level that's been holding steady for much of the past decade, new government figures show.

But the data also show a booming number of older women are taking calcium.

Federal officials released figures Wednesday showing that the use of dietary supplements has grown since the early 1990s when it was about 42 percent. The data shows use leveled off in 2003 through 2008, with about half of adults 20 and older taking at least one dietary supplement.

The biggest change was for calcium. Two-thirds of women 60 and older take it, up from 28 percent in the early 1990s.

Experts note the ranks of the elderly have been growing, and include many women who have been encouraged for years to take calcium to help protect against osteoporosis.

The information comes from national, in-home surveys in 1988-1994 and 2003-2008. The surveys in the past decade included more than 2,000 people each year. Interviewers not only asked participants what supplements they took, but also asked to see the bottles to verify their answers.

Use of multivitamins — the most popular supplement — crept up to nearly 40 percent.

Most people who take vitamins and other supplements are educated, have good incomes, eat pretty well and already get the nutrients they need from their diets, the surveys suggests.

"It's almost like the people who are taking them aren't the people who need them," said Regan Bailey, a nutritional epidemiologist with the National Institutes of Health.

Federal surveys have only recently started asking people why they take supplements, Bailey said.

The government supports some supplements as an option for certain people — such as iron for women who are pregnant, folic acid for women thinking of getting pregnant and calcium for older women.

But health officials say people should talk to their doctors first, and consider enriched foods that can accomplish the same goal.

Much of the new data is in a Centers for Disease Control and Prevention report released Wednesday. SOURCE

Online: CDC report: http://www.cdc.gov/nchs

Read more on Natural Health News

March 2011

Don’t Be a Victim of Drug Company Propaganda

It is in the economic interests of drug companies to steer Americans away from healthier lifestyles and dietary supplements. As more Americans fall ill to degenerative disease, drug company profits increase exponentially.

Enormous amounts of pharmaceutical dollars are spent influencing Congress, the FDA, and other federal agencies. The result is the promulgation of policies that cause Americans to be deprived of effective, low-cost means of protecting themselves against age-related disease.
The fact that the diets of more than 90% of Americans supply less than the 12 milligrams a day of vitamin E the government proclaims to be adequate is a startling revelation. It documents an epidemic deficiency of vitamin E among Americans who do not take supplements. Despite these grim statistics, the medical establishment continues to question the value of supplemental vitamin E. SOURCE

APRIL 2010
Help protect your right to supplements -

Alert: Protect Your Right To Natural and Bio-available Vitamin B-6!
ANH-USA On April 6, 2010 @ 3:18 pm

Human beings cannot live without vitamin B-6. It is also important for the prevention of cancer and the prevention and treatment of seizures, anemia, mental disorders including schizophrenia, carpal tunnel syndrome, and other conditions. Its effect on carpal tunnel can seem almost miraculous [1].

A natural form of the vitamin, Pyridoxamine, was recently yanked off the market by the FDA. Why? Because a pharmaceutical company, BioStratum, wanted sole use of pyridoxamine in a drug, a drug which may or may not ever appear. The company filed a so-called citizens petition and the FDA agreed, notwithstanding protests from ANH-USA, other organizations, and thousands of citizens. You might ask: how can Pharma take a supplement off the market and claim exclusive use of it as a prescription drug? The FDA does not presently feel obligated to answer this question.

Unfortunately, this isn’t all the bad news about vitamin B6. All forms of B-6, natural or synthetic, must be converted to P5P, another natural form, for the body to use it. Another drug company, Medicure Pharma, wants sole use of P5P and so has petitioned the FDA to ban its use as a supplement as well.

Medicure has yet to market a drug made from P5P, but wants the ban to take place now. And never mind that any individual unable to convert synthetic B6 to P5P would have to rely solely on Medicure’s product to stay alive.

How does Medicure think it can get away with this? Its petition states rather candidly: “Pharmaceutical companies developing new drugs must be protected from companies that may seek to market the ingredients in those drugs as dietary supplements. The marketing of such products has the potential to undermine the incentive for the development of new drugs because many people may choose to purchase the supplements rather than the drugs.”

This is not of course a case of supplement producers creating a product to compete with an existing prescription drug. It is just the reverse. P5P, the natural and bioactive form of B6, has existed in food for as long as there have been humans and has been available as a supplement for years. Medicure seems to be saying: If it seems profitable, let’s just turn a critical vitamin, one essential for human life, into a drug, make it available only by subscription, and mark up the price. This is truly outrageous.

The FDA has not yet responded to Medicure’s petition. We have asked you in the past to send a message to the FDA and Congress protesting Medicure’s P5P grab, and the time has come to send some more messages. So if you haven’t sent in a message to the FDA and Congress yet, or even if you have, please send one today [2].

[2]

While we are discussing Vitamin B6, here is the latest scientific report. An analysis of 13 U.S., European and Asian studies of vitamin B6 and colon cancer, conducted from 2002-2009, has been published in a special edition of the Journal of the American Medical Association. Studies of the range of B6 doses found that vitamin B6 taken in higher doses reduced the risk of colon cancer by 21 percent. In one study, Dr. Susanna Larsson and her colleagues at Sweden’s National Institute of Environmental Medicine reported an inverse relationship between the intake of vitamin B6 or pyridoxine and the risk of colon cancer. Dr. Larsson linked the effect to bloodstream levels of pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6 [3]. Pyridoxal-phosphate is also known as pyridoxal 5-phosphate or (as we referred to it above) P5P.

Don’t let the FDA take away our access to the natural and most bioavailable form of B6, P5P. Please take action now [2].


--------------------------------------------------------------------------------

Article printed from Alliance for Natural Health – US: http://www.anh-usa.org

URL to article: http://www.anh-usa.org/alert-protect-your-right-to-natural-and-bio-available-vitamin-b-6/

URLs in this post:

[1] Its effect on carpal tunnel can seem almost miraculous: http://search.vitasearch.com/search?q=pyridoxine+carpal+tunnel+syndrome&restrict=Summaries&site=CP&client=CP&proxystylesheet=CP&output=xml_no_dtd&filter=0&getfields=*

[2] please send one today: https://secure3.convio.net/aahf/site/Advocacy?cmd=display&page=UserAction&id=334

[3] inked the effect to bloodstream levels of pyridoxal-phosphate (PLP), the main active coenzyme form of vitamin B6: http://www.physorg.com/print187978106.html

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Posted in: ANH-USA,Big PhRMA,FDA,vitamin B6,vitamins

Where are the Niacin Studies for Schizophrenia?

from November 2009, timely today in regard to the discussion about psychiatry currently in the news.

Natural Mental Health

UPDATE 12/21 - Food Sources of Niacin (B3)

UPDATE: 12/18 - If you have been a proponent of natural mental health you would already have known that omega 3 EFAs have been an effective help to many who live with several mental health issues.

BETHESDA, Md., Dec. 18 (UPI) -- Deficiencies in omega-3 fatty acids may be a factor in mental illnesses, U.S. researchers suggest.

The study, published in Behavioral Neuroscience, named two omega-3 fatty acids -- docosahexaenoic acid and eicosapentaenoic acid -- as key to maintaining a nervous system capable of avoiding sensory overload.

The researchers suggest low omega-3 may be linked to the information-processing problems found in people with afflictions of the nervous system including schizophrenia and bipolar, obsessive-compulsive, attention-deficit hyperactivity disorders.

The researchers looked at nervous system function in the offspring of four groups of pregnant mice that had been fed different diets with no or varying types and amounts of omega-3s. Only the mice raised on the two omega-3 fatty acids showed normal, adaptive sensorimotor nervous responses that did not result in the animals being perpetually startled and easily overwhelmed by sensory stimuli.

"It is an uphill battle now to reverse the message that 'fats are bad,' and to increase omega-3 fats in our diet," study leader Norman Salem Jr. of the National Institute on Alcohol Abuse and Alcoholism in Bethesda said in a statement.

-----------------------------------------------------
Travelling back some 50 or more years ago there were some members of the medical profession who took a totally different look at mental health issues.  Instead of fluoride based anti-psychotics, these courageous fellows relied on nutritional supplementation and effectively treated thousands of people diagnosed as schizophrenic.

And to make it all the more respectable, numerous scientific reports were issued on this care that came to be known as orthomolecular medicine.

And you might wonder why PubMed fails to include the orthomolecular journal so you might be more able to find related data.

Schizophrenia and Schizoaffective Disorders
Double blind controlled therapeutic trials in Saskatchewan in 1952 showed that adding vitamin B-3 to the treatment then available, which was electro convulsive therapy, doubled the recovery rate. From this start, and corroborated by a large number of clinical studies and by one double blind corroborative study that was sponsored by National Institute of Mental Health, Washington, this early treatment has been refined and expanded. There are no negative studies. It now includes examination of the diet for possible food allergies; includes using optimum doses of vitamin B-3, which range from 3 to 12 or more grams daily; includes the use of vitamin C as an important antioxidant and other vitamins if needed, plus the best medication. As patients respond, the doses of medication and the nutrients are adjusted until the optimum doses of all nutrients and drugs is achieved. This treatment should be under medical control.

Nutrients Most Commonly Used For Schizophrenia and Schizo-Affective Disorders (under medical supervision):



* Vitamin B-3

* Vitamin C

* Vitamin B-6

* Zinc

* Vitamin B complex

* Selenium

Mood Disorders: Anxiety, Bipolar or Depression -
The following nutrients are helpful in controlling mood disorders (under medical supervision):


* Niacinamide

* B complex

* Vitamin C

* Folic acid

* Vitamin D

* Vitamin B-6
* Zinc citrate

* Essential fatty acids


In contrast to anti depressant medication I have not yet seen the type of warning issued by Professor Lana Watkins PhD, Duke University, who told the Annual meeting of the American Psychosomatic Society held in Denver, March 4, 2006, that current anti depressants increased the risk of dying from heart disease by 55 percent.

"Orthomolecular treatment does not lend itself to rapid drug-like control of symptoms, but patients get well to a degree not seen by tranquilizer therapists who believe orthomolecular therapists are prone to exaggeration. Those who've seen the results are astonished." 
---Abram Hoffer, M.D., Ph.D., 1917-2009

Read: http://naturalhealthnews.blogspot.com/2009/08/arthritis-drugs-pose-cancer-risk.html

FDA Okays New Antipsychotic for Schizophrenia, Bipolar Disorder
By Cole Petrochko, Staff Writer, MedPage Today, August 14, 2009

WASHINGTON -- The FDA approved the atypical antipsychotic asenapine (Saphris) for schizophrenia and bipolar disorder in adults, making it the first psychotropic drug to gain initial approval for both conditions.

The drug is indicated for first-line use in acute treatment of schizophrenia and of manic or mixed episodes in bipolar I disorder, with or without psychotic features.

FDA approval was based on data from more than 3,000 patients showing statistically significant efficacy versus placebo in acute schizophrenia trials and statistically significant reduction of bipolar mania symptoms versus placebo.

The drug showed signs of treating negative schizophrenia symptoms better than risperidone (Risperdal) in early clinical trials, but the advantage was not subsequently confirmed against olanzapine (Zyprexa, Zydis). (See APA: New Drug No Better for Negative Schizophrenia Symptoms)

Like other atypical antipsychotics, asenapine's side effects include sedation, weight gain, tardive dyskinesia, and diabetes risks. However, a clinical trial showed that asenapine's rate of weight gain was significantly lower than that experienced with olanzapine, a similar antipsychotic.

Atypical antipsychotics also show an increased likelihood of death in elderly patients treated for dementia-related psychosis.

The tablets are available in five and 10 mg doses and should be taken twice daily.

Manufacturer Schering-Plough said it plans to make the drug available in the fourth quarter of 2009.

Read more »

Posted in: antipsychotics,atypical antipsychotics,B3,food source of B3,food source of niacin,natural mental health,niacin,niacinamide,Omega 3,orthomolecular medicine,schizophrenia,vitamins

A Fool is Born

I took some time this morning to motor about 12 miles down the road to my service dealer for my rig's regular 3000 mile checkup and service.

I carried a book with me to pass the time while I waited in the showroom of the once Chrysler dealer, now showcasing a 66 Dodge Charger while the used cars of their trade fill the lot.

I read my fascinating book, written in 1892, for a while then picked up a few of the magazines for perusal.

In the rack was an April 2010 issue of Reader's Digest. Featured on the cover was this article about vitamins you'll find below.

The first myth of this writer is the falsity of being able to get adequate nutrition, vitamins and minerals, from today's food, even if it is organic.

The "tooth fairy" reference is insulting and I have to wonder who is this woman's audience, really!

She further denigrates multi-vitamin-mineral caps as almost like taking poison.

This woman must not know that if people with diabetes took a daily multi of good quality it would go far to help offset the problems of the dis-ease.

Once Upon A Time real science found that vitamin E prevented and reversed heart disease.

Once Upon A Time real science found that vitamin A, not beta carotene alone, helped prevent and reverse pneumonia.

Once Upon A Time real science found that not only did vitamin C prevent colds but it prevented and cured many health problems.

Once Upon A Time real science found that vitamins have a major role in preventing and booting recovery from mainstream cancer therapy today.  There is even a PhD researcher that spends all of his effort at his university studying vitamins for cancer.  Plus he IS a published author!

Oh, and yes, vitamin D is really a helpful hormone and yes, too many are deficient, and 1000 units a day might not be enough to build up your reserve.

Fortunately for me I know that drugs may not always help you and the truth and lies about them are often hidden so you won't think that might not be your best choice.

Fortunately for me I know that there is real science behind the use of orthomolecular medicine for health.

And hopefully you'll now be a bit wiser that to believe in the following hype.

5 Vitamin Truths and Lies

Are you still relying on vitamins to keep you healthy? Learn the truth about which supplements help and which ones you can toss.

Once upon a time, you believed in the tooth fairy. You counted on the stability of housing prices and depended on bankers to be, well, dependable. And you figured that taking vitamins was good for you. Oh, it's painful when another myth gets shattered. Recent research suggests that a daily multi is a waste of money for most people—and there's growing evidence that some other old standbys may even hurt your health. Here's what you need to know.

Myth: A multivitamin can make up for a bad diet

An insurance policy in a pill? If only it were so.

Last year, researchers published new findings from the Women's Health Initiative, a long-term study of more than 160,000 midlife women. The data showed that multivitamin-takers are no healthier than those who don't pop the pills, at least when it comes to the big diseases—cancer, heart disease, stroke. "Even women with poor diets weren't helped by taking a multivitamin," says study author Marian Neuhouser, PhD, in the cancer prevention program at the Fred Hutchinson Cancer Research Center, in Seattle. 

Vitamin supplements came into vogue in the early 1900s, when it was difficult or impossible for most people to get a wide variety of fresh fruits and vegetables year-round. Back then, vitamin-deficiency diseases weren't unheard-of: the bowed legs and deformed ribs of rickets (caused by a severe shortage of vitamin D) or the skin problems and mental confusion of pellagra (caused by a lack of the B vitamin niacin). But these days, you're extremely unlikely to be seriously deficient if you eat an average American diet, if only because many packaged foods are vitamin-enriched. Sure, most of us could do with a couple more daily servings of produce, but a multi doesn't do a good job at substituting for those. "Multivitamins have maybe two dozen ingredients—but plants have hundreds of other useful compounds," Neuhouser says. "If you just take a multivitamin, you're missing lots of compounds that may be providing benefits."

That said, there is one group that probably ought to keep taking a multi-vitamin: women of reproductive age. The supplement is insurance in case of pregnancy. A woman who gets adequate amounts of the B vitamin folate is much less likely to have a baby with a birth defect affecting the spinal cord. Since the spinal cord starts to develop extremely early—before a woman may know she's pregnant—the safest course is for her to take 400 micrograms of folic acid (the synthetic form of folate) daily. And a multi is an easy way to get it. 

Myth: Vitamin C is a cold fighter

In the 1970s, Nobel laureate Linus Pauling popularized the idea that vitamin C could prevent colds. Today, drugstores are full of vitamin C–based remedies. Studies say: Buyer, beware.

In 2007, researchers analyzed a raft of studies going back several decades and involving more than 11,000 subjects to arrive at a disappointing conclusion: Vitamin C didn't ward off colds, except among marathoners, skiers, and soldiers on subarctic exercises.

Of course, prevention isn't the only game in town. Can the vitamin cut the length of colds? Yes and no. Taking the vitamin daily does seem to reduce the time you'll spend sniffling—but not enough to notice. Adults typically have cold symptoms for 12 days a year; a daily pill could cut that to 11 days. Kids might go from 28 days of runny noses to 24 per year. The researchers conclude that minor reductions like these don't justify the expense and bother of year-round pill-popping (taking C only after symptoms crop up doesn't help).

Myth: Vitamin pills can prevent heart disease 

Talk about exciting ideas—the notion that vitamin supplements might help lower the toll of some of our most damaging chronic diseases turned a sleepy area of research into a sizzling-hot one. These high hopes came in part from the observation that vitamin-takers were less likely to develop heart disease. Even at the time, researchers knew the finding might just reflect what's called the healthy user effect—meaning that vitamin devotees are more likely to exercise, eat right, and resist the temptations of tobacco and other bad habits. But it was also possible that antioxidant vitamins like C, E, and beta-carotene could prevent heart disease by reducing the buildup of artery-clogging plaque. B vitamins were promising, too, because folate, B6, and B12 help break down the amino acid homocysteine—and high levels of homocysteine have been linked to heart disease.

Unfortunately, none of those hopes have panned out. 

An analysis of seven vitamin E trials concluded that it didn't cut the risk of stroke or of death from heart disease. The study also scrutinized eight beta-carotene studies and determined that, rather than prevent heart disease, those supplements produced a slight increase in the risk of death. Other big studies have shown vitamin C failing to deliver. As for B vitamins, research shows that yes, these do cut homocysteine levels …but no, that doesn't make a dent in heart danger. 

Don't take these pills, the American Heart Association says. Instead, the AHA offers some familiar advice: Eat a varied diet rich in fruits, vegetables, and whole grains. 

Myth: Taking vitamins can protect against cancer 

Researchers know that unstable molecules called free radicals can damage your cells' DNA, upping the risk of cancer. They also know that antioxidants can stabilize free radicals, theoretically making them much less dangerous. So why not take some extra antioxidants to protect yourself against cancer? Because research so far has shown no good comes from popping such pills.

A number of studies have tried and failed to find a benefit, like a recent one that randomly assigned 5,442 women to take either a placebo or a B-vitamin combo. Over the course of more than seven years, all the women experienced similar rates of cancers and cancer deaths. In Neuhouser's enormous multivitamin study, that pill didn't offer any protection against cancer either. Nor did C, E, or beta-carotene in research done at Harvard Medical School. 

Myth: Hey, it can't hurt

The old thinking went something like this—sure, vitamin pills might not help you, but they can't hurt either. However, a series of large-scale studies has turned this thinking on its head, says Demetrius Albanes, MD, a nutritional epidemiologist at the National Cancer Institute.

The shift started with a big study of beta-carotene pills. It was meant to test whether the antioxidant could prevent lung cancer, but researchers instead detected surprising increases in lung cancer and deaths among male smokers who took the supplement. No one knew what to make of the result at first, but further studies have shown it wasn't a fluke—there's a real possibility that in some circumstances, antioxidant pills could actually promote cancer (in women as well as in men). Other studies have raised concerns that taking high doses of folic acid could raise the risk of colon cancer. Still others suggest a connection between high doses of some vitamins and heart disease. 

Vitamins are safe when you get them in food, but in pill form, they can act more like a drug, Albanes says—with the potential for unexpected and sometimes dangerous effects.

Truth: A pill that's worth taking

As studies have eroded the hopes placed in most vitamin supplements, one pill is looking better and better. Research suggests that vitamin D protects against a long list of ills: Men with adequate levels of D have about half the risk of heart attack as men who are deficient. And getting enough D appears to lower the risk of at least half a dozen cancers; indeed, epidemiologist Cedric Garland, MD, at the University of California, San Diego, believes that if Americans got sufficient amounts of vitamin D, 50,000 cases of colorectal cancer could be prevented each year.

But many—perhaps most—Americans fall short, according to research by epidemiologist Adit Ginde, MD, at the University of Colorado, Denver. Vitamin D is the sunshine vitamin: You make it when sunlight hits your skin. Yet thanks to sunscreen and workaholic (or TV-aholic) habits, most people don't make enough.

How much do you need? The Institute of Medicine is reassessing that right now; most experts expect a big boost from the current levels (200 to 600 IU daily). It's safe to take 1,000 IU per day, says Ginde. "We think most people need at least that much."

So here's the Reader's Digest Version of the truth about vitamins: Eat right, and supplement with vitamin D. That's a no-brainer coupled with a great bet—and that's no lie.

What a panel of doctors and others have to say about the RD nonsense...

"From start to finish, the Reader's Digest article, '5 Vitamin Truths and Lies' was one of the worst bits of propaganda I ever saw. There was not one word in it discussing the benefits of multivitamins, vitamin C, and studies supporting the use of vitamins for preventing cancer and heart disease. Not once was a single dose mentioned. This alone makes the entire effort a farce aimed at a readership that is relying on the publication for accurate information."
Allan N. Spreen, M.D. (Mesa, AZ)
"Vitamins are among the safest substances known. They have the most minimal side effects, even in large doses, compared with the death rate due to conventional drugs taken according to the manufacturers' advice. Vitamin C is among the most powerful immune modulators if given in large doses. Scare stories against the use of vitamins do the public no good."
Erik Paterson, M.D. (Vancouver, BC)
"This is not the first time Reader's Digest has written about "bad" vitamins, and they always seem to manage to put it on the front page. But look at their advertising: so much of it is for pharmaceutical drugs. No wonder the article states virtually nothing of the thousands of positive results with vitamins."
James A. Jackson, Ph.D. (Wichita, KS)
"The author of the Reader's Digest article has not understood the articles used to support her arguments. For example, with vitamin C and the common cold, the article appears to refer to the 2007 Cochrane report. However, this report has been updated frequently since 2007. The last update was on February 2nd of this year. Either the reporter did not read the up-to-date review, or she was unable to understand its content. The review applies only to low intakes, and contains major objections that studies of large doses and orthomolecular intakes were not included. All the data were for intakes far below the levels actually claimed to be effective. The summary of the paper does indeed give a misleading impression, but people might expect an intelligent reporter to check the rest of the report before giving advice."
Steve Hickey, Ph.D. (Manchester, UK)
"The material was not well-researched, and a bias was clearly in play. 15 pages of drug advertisements in that issue of Reader's Digest is very telling, indeed."
Thomas E. Levy, M.D. (Colorado Springs, CO)
"What a poor job! Reader's Digest needs to review the literature. Haven't they read any articles by Dr. Bruce Ames? Do they know what quantities of vitamin C ascorbic were used in the cold studies mentioned in their one-sided report? Do they know of the high doses that showed benefit? Do they know of the many studies that have reported benefit from vitamin E and carotenes? It's easy to be ignorant but biased. Before a magazine does such a public health disservice, first get the all the facts."
Michael J. Gonzalez, Ph.D. (San Juan, PR)
"As a family practitioner who has prescribed vitamins for many reasons, with beneficial results over the past 25 years, I have removed Reader's Digest from my waiting room. Unless there is a follow-up article disclaiming most of what was written, I will discourage my patients from reading Reader's Digest because of their biased and misleading information."
Stephen Faulkner, M.D. (Duncan, BC)
Owen Fonorow of The Vitamin C Foundation adds:
"Why did Reader's Digest deem it appropriate to publish unbalanced opinions about the value of vitamins in the April 2010 issue? A balanced report would have quoted experts from both sides of the argument. The negative studies of vitamins are biased, utilizing too small amounts, especially of vitamin C, to fairly evaluate the therapeutic use of the vitamins. There is a 70-year-long history of vitamin C research (now more than 80,000 papers) that consistently shows therapeutic results at higher dosages of many thousands of milligrams. Linus Pauling recommended at least 5,000 mg of vitamin C daily for reversing heart disease. It is a serious public health mistake for Reader's Digest to recommend against a multivitamin."
To give Reader's Digest one more chance at the truth, send your thoughts directly to the people responsible: RDEditorial_RDW@ReadersDigest.com
To learn more about how high doses of vitamins safely and effectively fight disease: http://orthomolecular.org/resources/omns/index.shtml

the above article is with thanks to a loyal reader!

Upper Respiratory Infection (URI) and Vitamin C
Naama Constantini, MD, DFM, FACSM, Dip. Sport Med. (CASM) Director-Sport Medicine Center, Department of Orthopedic Surgery, The Hadassah-Hebrew University Medical Center, Jerusalem 4 Ha'razim St., Jerusalem, Israel

"The Effect Of Vitamin C On Upper Respiratory Infections In Adolescent Swimmers: A Randomized Trial,"
Eur J Pediatr, 2010 August 6; [Epub ahead of print]. 48142 (10/2010)

Yes, it worked! 

a beneficial role for vitamin C in sepsis

Research conducted at the University of Western Ontario and Lawson Health Research Institute has uncovered a beneficial role for vitamin C in sepsis, an immune system reaction to bacterial infection that results in the formation of blood clots, impaired blood flow and potential organ failure. The condition occurs mainly in infants, individuals with impaired immune systems, and older men and women. The current study's findings were reported in the November, 2010 issue of the journal Intensive Care Medicine.

Severe sepsis carries a mortality rate of 40 percent, according to University of Western Ontario Schulich School of Medicine & Dentistry professor Karel Tyml. Capillaries that have been blocked by blood clots, caused by oxidative stress and activation of the blood clotting pathway, are the cause of multiple organ failure and death in septic patients. "There are many facets to sepsis, but the one we have focused on for the past 10 years is the plugging of capillaries," he noted. Dr Tyml's laboratory was the first to discover this phenomenon via the use of intravital microscopy.

In experiments with three strains of mice, Dr Tyml's team demonstrated that vitamin C administered intravenously early in the development of sepsis prevents capillary blockage as well as reverses the condition by restoring blood flow if administered later. Reversal of blood flow blockage by vitamin C appeared to be dependent upon the production of nitric oxide, which dislodges platelets from the capillary wall.

"Our research in mice with sepsis has found that early as well as delayed injections of vitamin C improves chance of survival significantly," Dr Tyml remarked. "Furthermore, the beneficial effect of a single bolus injection of vitamin C is long lasting and prevents capillary plugging for up to 24 hours post-injection."

"Vitamin C is cheap and safe," he added. "Previous studies have shown that it can be injected intravenously into patients with no side effects. It has the potential to significantly improve the outcome of sepsis patients world-wide. This could be especially beneficial in developing countries where sepsis is more common and expensive treatments are not affordable."

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Posted in: Christie Aschwanden,Readers Digest,vitamins

Antioxidants aid arterial health

Who needs Liptor when antioxidant vitamins and minerals, good nutrition, and other health promoting activities like exercise keep your innards healthy while improving cardiovascular health -- better blood sugar and better cholesterol profiles.?

HOLON, Israel, July 7 (UPI) -- Vitamin C, vitamin E, co-enzyme Q10 and selenium supplement had beneficial effects for those with cardiovascular risk factors, researchers in Israel said.
Reuven Zimlichman and colleagues at the Wolfson Medical Center in Israel said the study involved 70 patients from the center's hypertension clinic.
"Antioxidant supplementation significantly increased large and small artery elasticity in patients with multiple cardiovascular risk factors," Zimlichman said in a statement. "This beneficial vascular effect was associated with an improvement in glucose and lipid metabolism as well as significant decrease in blood pressure."
The research team randomized the 70 patients to receive either antioxidants or placebo capsules for six months.
The study, published in the journal Nutrition  Metabolism, found that at the three-month and six-month mark, patients in the antioxidant group had more elastic arteries -- a measure of cardiovascular health -- better blood sugar and better cholesterol profiles.

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Posted in: arteriosclerosis,blood sugar,cholesterol,heart health,minerals,statins,vitamins

Older Adults Need More Vitamin D

Not only do older people require more vitamin D, but so do people of color, people who do not go in the sun, those wearing clothing that fully covers the body from head to toe, but those dealing with obesity (this group may need up to 5x greater doses).

Find our many articles on Vitamin D using the search box.  You can also order the vitamin D test and your quality vitamin D supplements to help support Natural Health News.

By Mike Stones, 18-May-2010

Older adults suffering vitamin D deficiency need higher remedial doses than younger adults, according to a new research review.

The study, Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D3 than younger adults?, concluded that: “The doses and total time for repleting older adults with vitamin D3 appeared to be greater than for younger adults, in part due to the lower starting baseline vitamin D status.”

Oral supplementation

To ensure almost all patients receive sufficient vitamin D, a daily dose of 125 mcg (5000 IU) is required for older people, aged 65 and above, while for younger patients, below the age of 65, a rate above 50 mcg (2000 IU) was sufficient.

The results applied whether Vitamin D was taken daily or as a bolus oral supplementation. Adults classed as deficient were those with levels of 25-hydroxyvitamin D less than 75 nmol/L.

The researchers further concluded that several regimens, such as loading with a high dose (12500 mcg) of vitamin D3 and then giving 1250 mcg monthly, provide enough vitamin D3 for most patients to achieve and maintain 25(OH)D levels at or above 75 nmol/L.

According to the research review, a promising loading regimen is to provide calcidiol (25(OH)D) itself.

Since information on repletion with vitamin D2 has been published recently, the researchers decided to focus on the use of vitamin D3 from dietary supplements, prescriptions for large oral doses, and bolus dosing or injections.

Most published dosing regimens failed to achieve 75 nmol/L in almost all subjects, whether young adults (below 65 years) or older adults (above 65 years).

The authors, Susan Whiting, College of Pharmacy and Nutrition, University of Saskatchewan, Canada, and Mona Calvo, US Food and Drug Administration, noted many differences among studies, including baseline levels, endpoints, study duration, and compliance.

Adverse effects

All the studies reviewed reported that subjects were free of adverse effects, indicating that the vitamin D3 protocols were safe during the observed dosing periods.

Meanwhile, the researchers noted that: “Vitamin D insufficiency and deficiency is at epidemic proportions worldwide. In temperate countries more than half of the population is at risk and worldwide, even in tropical countries, vitamin D deficiency is a very serious concern due to changes in living and working conditions.”

Vitamin D has been shown convincingly to have many functions beyond its role in calcium and bone health, they added.

In addition to maintaining normal blood levels of calcium and phosphorus, Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. Recently, research also suggests vitamin D may provide protection from osteoporosis, hypertension, cancer, and several autoimmune diseases.

Source: Molecular Nutrition and Food Research -

Title: Correcting poor vitamin D status: Do older adults need higher repletion doses of vitamin D3 than younger adults? Authors: S. Whiting, M.Calvo

Older adults need higher remedial doses of vitamin D deficiency: Study: "Older adults suffering vitamin D deficiency need higher remedial doses than younger adults, according to a new research review."

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Posted in: older adults need more vitamin D,supplements,Vitamin D,vitamins

News BUZZ not worth the words: Vitamins & Breast Cancer

I just heard Wolf Blitzer report on this story, and I heard it on the noon news today, as well as in an email sent to me yesterday.

Knowing this infinitesimal bit of BUZZ, I am sure this will be all over the evening network news, and regular news for days. Sanjay Gupta is just about to reply on this "headliner". Gupta says it is an association that something in a multi-vitamin may lead to this 19% reported increased risk.  He also gives that tired and  biased caveat about being able to get all you nutrition from your diet. Not a chance if you eat like those people Jaime Oliver is trying to educate.

If you are a thinking person, please to not fall prey to this BUZZ glut.

And please take the time to review the following commentary I developed at the request of a major news director who is interested in reporting fact, not BUZZ. It is a well known fact that the more times you hear sound bites, the faster you tend to believe them.

Don't become a sheeple...and please read this excerpt from my comments - it is your best insurance against propaganda spread via mainstream media, talking heads, and Big PhRMA. (for the complete article, request it by contacting me)
  
A Word to the Wise By Gayle Eversole, DHom, PhD, MH, NP, ND

In an article recently published on the web site eFitnessNow. a group of people provide you with what they believe to be useful health oriented information.I looked over this entire website and no where could I find any information about the staff and their qualifications as editors, or any information about their backgrounds in health or related health professions.

This may appear cynical on the surface, but it is important to understand today’s way of providing “news” and the way in which it can affect your beliefs.

Recently I listened to an interview on NPR addressing MRSA.I have an interest in this topic as it is something I have been working on with natural and creative approaches since 1993.

I realized that all the journalist-author really did in her book was to compile an amount of data that had already been reported in the news. She also spoke with “researchers” about whom these news articles had been written. There are a lot of reports of findings, yet no constructive outcome or effective treatment has been discovered.

The author and interviewer also avoided looking at other options that the accepted standard mainstream models.

This brings me to an article I posted on my blog, Natural Health News, in February 2009, titled ‘How Mainstream Media Distorts Health Information”. 

We know that there is, and has been, a directed effort to limit you access to vitamins and supplements, and an effort also to try to sway your opinion to the ideas that you can get all the needed nutrients from food and supplements do not help prevent or heal disease.

These concepts have been proven, over and over again, to be false.

But, you must consider that this article reports only a ‘meta-anlysis’.

A meta-analysis is a statistical method attributed to Gene Glass, as defined in the following synopsis -
http://www.bii.a-star.edu.sg/docs/mig/MetaAnalysis.pdf
•In 1976, Glass coined the term meta-analysis
http://glass.ed.asu.edu/gene/papers/meta25.html
http://en.wikipedia.org/wiki/Gene_V._Glass
statistical analysis of a large collection of analysis results from individual studies for the purpose of integrating the findings.(Glass, 1976, p3)
•Meta-analysis techniques are needed because only summary statistics are typically available in the literature.
•Often used in medical and psychological studies.

Now that you have the background information, let’s move on to the article in question, as reported by eFitnessNow.

A startling connection between multi-vitamins and breast cancer occurrence has prompted doctors to caution older women against a daily multi-vitamin, unless absolutely needed. According to the results of a Swedish study, the vitamins may be linked to breast cancer.
The authors of the study cannot outright confirm the correlation between the two but suggest the matter needs further research. The study was led by Dr. Susanna C. Larsson of the Karolinska Institute in Stockholm. The study followed 35,000 Swedish women between the ages of 49 and 83 over a ten year period. All the women were cancer free at the onset, with 974 developing breast cancer throughout the course of the study.
Women who took daily vitamins were 19 percent more likely to develop breast cancer. 9,000 women in the study were vitamin users with 293 developing the often fatal disease. Only 681 of the remaining 26,000 women developed breast cancer. A relatively small number of women who took the daily vitamins were diagnosed with breast cancer, which lends to the suggestion that if there is a risk, it is very modest.
Larsson advises that women who are eating a well-balanced diet do not need a multi-vitamin.
The study has been published in the American Journal of Clinical Nutrition.

When you analyze this statement, “The study followed 35,000 Swedish women between the ages of 49 and 83 over a ten year period. All the women were cancer free at the onset, with 974 developing breast cancer throughout the course of the study.”, you find that the statistical impact is 0.02%.
 
If you analyze this statement, “Women who took daily vitamins were 19 percent more likely to develop breast cancer. 9,000 women in the study were vitamin users with 293 developing the often fatal disease.” , you find that the statistical impact is 0.03%.
 
And if you analyze this statement, “Only 681 of the remaining 26,000 women developed breast cancer.” , you find that the statistical impact is 0.02%.
 
And in conclusion, the report says, “A relatively small number of women who took the daily vitamins were diagnosed with breast cancer, which lends to the suggestion that if there is a risk, it is very modest.”

The moral of this story is don’t be fooled by headlines, and yes, digest what you read.

If you do a search for Dr. Susanna C. Larrson you can locate over one hundred articles based on meta-analysis of existing research. She has yet to respond to the inquiry I sent.  Also note that there is no definition of exactly what multi-vitamins were used in the studies.

This is a critical concern, as most vitamin studies done in the mainstream use low quality, synthetic or too low dose products.

Complete article posted here

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Posted in: breast cancer,how to skew people's thinking,Jamie Oliver,Sanjay Gupta,sheeple,Susanna Larrson,vitamins,vitamins and breast cancer,vitamins prevent cancer

Vitamins for Alzheimer's

September 2010 Good News for B Vitamins and Your Brain
Ranks now in the TOP10 out of 3.9 M

Access the May 2007 issue of herbalYODA Says! that focuses on vitamin B12 with a donation to help us continue this work.
Elder Health
Updated from May 09
2004 Article,  Don't Overlook There ALZ Remiders, Related NHN article  This post ranks 1 of 1.23 Million about vitamins for Alzheimer's

Food and Life

for information on how to use B3 therapeutically, contact us for our fact sheet

UPDATE: 4 May, 2009

No wonder vitamin E works, it is antioxidant and carries O2 across the cell wall membrane as well as offering a myriad of other remarkable healing attributes.

Another FAT soluble vitamin to the rescue!

Use the search window to learn more about vitamin E on Natural Health News

Vitamin E may slow Alzheimer's disease By Megan Rauscher
NEW YORK (Reuters Health) – An analysis of "real-world" clinical data indicates that vitamin E, and drugs that reduce generalized inflammation, may slow the decline of mental and physical abilities in people with Alzheimer's disease (AD) over the long term.

"Our results are consistent for a potential benefit of vitamin E on slowing functional decline and a smaller possible benefit of anti-inflammatory medications on slowing cognitive decline in patients suffering from Alzheimer's disease," Dr. Alireza Atri told Reuters Health.

Atri, at Massachusetts General Hospital (MGH), the VA Bedford Medical Center, and Harvard Medical School, Boston, led the National Institutes of Health-sponsored research. The findings, reported at the annual meeting of the American Geriatrics Society in Chicago, stem from data on 540 patients treated at the MGH Memory Disorders Unit.

All of the patients were receiving standard-of-care treatment with a drug intended to help patients with Alzheimer's. As part of their clinical care, 208 patients also took vitamin E but no anti-inflammatory, 49 took an anti-inflammatory but no vitamin E, 177 took both vitamin E and an anti-inflammatory, and 106 took neither.

While the daily dose of vitamin E ranged from 200 to 2000 units, the majority of patients were given high doses that ranged from 800 units daily to 1000 units twice daily.

Each patient's performance on cognitive tests and their ability to carry out daily functions such as dressing and personal care were assessed every 6 months. After an average of 3 years, "there was a modest slowing of decline in function in those patients taking vitamin E," study investigator Michael R. Flaherty noted in a telephone interview with Reuters Health.

Flaherty, a second-year student at the University of New England College of Osteopathic Medicine in Biddeford, Maine, presented the findings at the meeting. He added that the treatment benefit from vitamin E was "small to medium" but increased with time.

Taking an anti-inflammatory medication was associated with "very consistent but generally only small effects on slowing long-term decline in cognitive functioning," Atri told Reuters Health.

However, in patients who took both vitamin E and anti-inflammatory medications, there appeared to be an additive effect in terms of slowing overall decline.

Given that past studies have produced equivocal results, the investigators conclude that further studies are needed to assess the long-term balance of risks versus benefits for people with Alzheimer's disease from taking vitamin E and anti-inflammatory drugs.

Copyright © 2009 Reuters Limited.

-------------------------

UPDATE: 23 MARCH, 2009

Niacin Protects against Alzheimer's Disease and Age-related Cognitive Decline

Niacin (vitamin B3) is already known to lower cholesterol. Now, research published in the August 2004 issue of the Journal of Neurology, Neurosurgery and Psychiatry indicates regular consumption of niacin-rich foods also provides protection against Alzheimer's disease and age-related cognitive decline.

Researchers from the Chicago Health and Aging Project interviewed 3,718 Chicago residents aged 65 or older about their diet, then tested their cognitive abilities over the following six years.

Those getting the most niacin from foods (22 mg per day) were 70% less likely to have developed Alzheimer's disease than those consuming the least (about 13 mg daily), and their rate of age-related cognitive decline was significantly less. In addition to eating the niacin-rich foods, another way to boost your body's niacin levels is to eat more foods rich in the amino acid tryptophan. Your body can convert tryptophan to niacin, with a little help from other B vitamins, iron and vitamin C. Foods high in tryptophan include shrimp, crimini mushrooms, yellowfin tuna, halibut, chicken breast, scallops, salmon, turkey and tofu. As you can see, several foods rich in tryptophan provide two ways to increase niacin levels as they are also rich in the B vitamin.(August 23, 2004)

UPDATE: 12 March, 2009

Another supplement to help Alzheimer's: "One of the newer drugs developed in Europe apparently 'works' by protecting brain cells from damage by over-production of glutamate, one of the well known actions of lithium.

Other research findings strongly suggest that lithium may protect against Alzheimer's disease and slow the progression of the disease. Lithium inhibits beta-amaloid secretion and protects against damage caused by beta-amyloid protein after it has formed.

Over-activation of tau protein in the brain also contributes to neuronal degeneration in Alzheimer's disease, as does the formation of neurofibrilary tangles. Lithium inhibits both of these.

People with Alzheimer's have excess aluminum accumulation in brain cells. Lithium can help protect against aluminum accumulation through chelation and easier removal from the body."

See also a related B3 article I posted in November - xref: Fetal Alcohol Syndrome.

-----------------------------

While we are on this thread of natural help for dis-ease isn't it timely that I just received this article about how "High Doses of Vitamins Fight Alzheimer's Disease".

And now I am sharing it with you, for your education, and then you can ask your doctor why they aren't recommending them.

Vitamin B3 is also used successfully for schizophrenia, rheumatoid arthritis, arthritis, reducing plaque of arteriosclerosis and cholesterol reduction. It has an excellent anti-inflammatory action.

(OMNS, December 9, 2008) The news media recently reported that "huge doses of an ordinary vitamin appeared to eliminate memory problems in mice with the rodent equivalent of Alzheimer's disease." They then quickly added that "scientists aren't ready to recommend that people try the vitamin on their own outside of normal doses." (1)

In other words, extra-large amounts of a vitamin are helpful, so don't you take them!

That does not even pass the straight-faced test. So what's the story?

Researchers at the University of California at Irvine gave the human dose equivalent of 2,000 to 3,000 mg of vitamin B3 to mice with Alzheimer's. (2) It worked. Kim Green, one of the researchers, is quoted as saying, "Cognitively, they were cured. They performed as if they'd never developed the disease."



for information on how to use B3 therapeutically, contact us for our fact sheet

Specifically, the study employed large amounts of nicotinamide, the vitamin B3 widely found in foods such as meat, poultry, fish, nuts and seeds. Nicotinamide is also the form of niacin found, in far greater quantity, in dietary supplements. It is more commonly known as niacinamide. It is inexpensive and its safety is long established. The most common side effect of niacinamide in very high doses is nausea. This can be eliminated by taking less, by using regular niacin instead, which may cause a warm flush, or choosing inositol hexaniacinate, which does not. They are all vitamin B3.
HealthDay Reporter mentioned how cheap the vitamin is; the study authors "bought a year's supply for $30" and noted that it "appears to be safe." Even so, one author said that "I wouldn't advocate people rush out and eat grams of this stuff each day." (1)
The BBC quoted Rebecca Wood, Chief Executive of the UK Alzheimer's Research Trust, who said, "Until the human research was completed, people should not start taking the supplement. . . . people should be wary about changing their diet or taking supplements. In high doses vitamin B3 can be toxic." (3)
The Irish Times reiterated it: "People have been cautioned about rushing out to buy high dose vitamin B3 supplements in an attempt to prevent memory loss . . . The warnings came today one day on from the announcement . . .Vitamins in high doses can be toxic." (4)
Their choice of words is quaint but hardly accurate. There is no wild "rush;" half of the population already takes food supplements. And as for "toxic," niacin isn't. Canadian psychiatrist Abram Hoffer, M.D., asserts that it is actually remarkably safe. "There have been no deaths from niacin supplements," Dr. Hoffer says. "The LD 50 (the dosage that would kill half of those taking it) for dogs is 5,000-6,000 milligrams per kilogram body weight. That is equivalent to almost a pound of niacin per day for a human. No human takes 375,000 milligrams of niacin a day. They would be nauseous long before reaching a harmful dose." Dr. Hoffer conducted the first double-blind, placebo-controlled clinical trials of niacin. He adds, "Niacin is not liver toxic. Niacin therapy increases liver function tests. But this elevation means that the liver is active. It does not indicate an underlying liver pathology."
The medical literature repeatedly confirms niacin's safety. Indeed, for over 50 years, nutritional (orthomolecular) physicians have used vitamin B3 in doses as high as tens of thousands of milligrams per day. Cardiologists frequently give patients thousands of milligrams of niacin daily to lower cholesterol. Niacin is preferred because its safety margin is so very large. The American Association of Poison Control Centers' Toxic Exposure Surveillance System annual reports indicates there is not even one death per year due to niacin in any of its forms. (5)
One the other hand, there are 140,000 deaths annually attributable to properly prescribed prescription drugs. (6) And this figure is just for one year, and just for the USA. Furthermore, when overdoses, incorrect prescription, and adverse drug interactions are figured in, total drug fatalities number over a quarter of a million dead. Each year.
The BBC's curious mention that we should even be "wary about changing our diets" is especially odd. More and more scientists think our much-in-need-of-improvement diets are what contribute more than anything to developing Alzheimer's. "There appears to be a statistically significant link between a low dietary intake of niacin and a high risk of developing Alzheimer's disease. A study of the niacin intake of 6158 Chicago residents 65 years of age or older established that the lower the daily intake of niacin, the greater the risk of becoming an Alzheimer's disease patient." The group with the highest daily intake of niacin had a 70 percent decrease in incidence of this disease compared to the lowest group. "The most compelling evidence to date is that early memory loss can be reversed by the ascorbate (vitamin C) minerals. Greater Alzheimer's disease risk also has been linked to low dietary intake of vitamin E and of fish." (7)
Nutrient deficiency of long standing may create a nutrient dependency. A nutrient dependency is an exaggerated need for the missing nutrient, a need not met by dietary intakes or even by low-dose supplementation. Robert P. Heaney, M.D., uses the term "long latency deficiency diseases" to describe illnesses that fit this description. He writes: "Inadequate intakes of many nutrients are now recognized as contributing to several of the major chronic diseases that affect the populations of the industrialized nations. Often taking many years to manifest themselves, these disease outcomes should be thought of as long-latency deficiency diseases. . . Because the intakes required to prevent many of the long-latency disorders are higher than those required to prevent the respective index diseases, recommendations based solely on preventing the index diseases are no longer biologically defensible." (8) Where pathology already exists, unusually large quantities of vitamins may be needed to repair damaged tissue. Thirty-five years ago, in another paper, Hoffer wrote: "The borderline between vitamin deficiency and vitamin-dependency conditions is merely a quantitative one when one considers prevention and cure." (9)
As there is no recognized cure for Alzheimer's, prevention is vital. In their article, the Irish Times does admit that "Healthy mice fed the vitamins also outperformed mice on a normal diet" and quoted study co-author Frank LaFerla saying that "This suggests that not only is it good for Alzheimer's disease, but if normal people take it, some aspects of their memory might improve." (4) And study author Green added, "If we combine this with other things already out there, we'd probably see a large effect."
The US Alzheimer's Association's Dr. Ralph Nixon has said that previous research has suggested that vitamins such as vitamin E, vitamin C and vitamin B12 may help people lower their risk of developing Alzheimer's disease. At their website (although you have to search for it), the Alzheimer's Association says, "Vitamins may be helpful. There is some indication that vitamins, such as vitamin E, or vitamins E and C together, vitamin B12 and folate may be important in lowering your risk of developing Alzheimer's. . . One large federally funded study (10) showed that vitamin E slightly delayed loss of ability to carry out daily activities and placement in residential care."
But overall, at their website http://www.alz.org/index.asp the Alzheimer's Association has strikingly little to say about vitamins, and they hasten to tell people that "No one should use vitamin E to treat Alzheimer's disease except under the supervision of a physician." ( http://www.alz.org/alzheimers_disease_10428.asp ) "They write as if these safe vitamins are dangerous drugs, not be used without a doctor's consent," comments Dr. Hoffer. "I have been using them for decades."
Niacin and nerves go together. Orthomolecular physicians have found niacin and other nutrients to be an effective treatment for obsessive compulsive disorder, anxiety, bipolar disorder, depression, psychotic behavior, and schizophrenia. New research confirms that niacinamide (the same form of B3 used in the Alzheimer's research) "profoundly prevents the degeneration of demyelinated axons and improves the behavioral deficits" in animals with an illness very similar to multiple sclerosis. (11)
A measure of journalistic caution is understandable, especially with ever-new promises for pharmaceutical products. Drugs routinely used to treat Alzheimer's Disease have had a disappointing, even dismal success rate. So when nutrition may be the better answer, foot-dragging is inexplicable, even inexcusable. Nutrients are vastly safer than drugs. Unjustified, needlessly negative opinionating is out of place. Over 5 million Americans now have Alzheimer's disease, and the number is estimated to reach 14 million by 2050. Potentially, 9 million people would benefit later from niacin now.
"Man is a food-dependent creature," wrote University of Alabama professor of medicine Emanuel Cheraskin, M.D.. "If you don't feed him, he will die. If you feed him improperly, part of him will die."
When that part is the brain, it is dangerous to delay the use of optimum nutrition.

References:

(1) Vitamin Holds Promise for Alzheimer's Disease. Randy Dotinga, HealthDay Reporter, Nov 5, 2008.

http://www.washingtonpost.com/wp-dyn/content/article/2008/11/05/AR2008110502796.html and also http://health.yahoo.com/news/healthday/vitaminholdspromiseforalzheimersdisease.html

(2) Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci. 2008 Nov 5;28(45):11500-10.

(3) BBC, 5 Nov 2008. http://news.bbc.co.uk/2/hi/health/7710365.stm

(4) Donnellan E. Caution urged over using vitamin B3 to treat Alzheimer's. Wed, Nov 05, 2008. http://www.irishtimes.com/newspaper/breaking/2008/1105/breaking91.htm

(5) Annual Reports of the American Association of Poison Control Centers' National Poisoning and Exposure Database (formerly known as the Toxic Exposure Surveillance System). AAPCC, 3201 New Mexico Avenue, Ste. 330, Washington, DC 20016. Download any report from1983-2006 at http://www.aapcc.org/dnn/NPDS/AnnualReports/tabid/125/Default.aspx free of charge. The "Vitamin" category is usually near the end of the report.

(6) Classen DC, Pestotnik SL, Evans RS, Lloyd JF, Burke JP. Adverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality. JAMA. 1997 Jan 22-29;277(4):301-6.

(7) 21. Hoffer A and Foster HD. Feel Better, Live Longer With Vitamin B-3: Nutrient Deficiency and Dependency. CCNM Press, 2007. ISBN-10: 1897025246; ISBN-13: 978-1897025246. Also: Foster HD. What Really Causes Alzheimer's Disease. Trafford, 2004. ISBN 1-4120-4921-0.

(8) Heaney RP: Long-latency deficiency disease: insights from calcium and vitamin D. Am J Clin Nutr. 2003; Nov; 78(5):912-9.

(9) Hoffer A. Mechanism of action of nicotinic acid and nicotinamide in the treatment of schizophrenia. In: Hawkins D and Pauling L: Orthomolecular Psychiatry: Treatment of Schizophrenia. San Francisco: W.H. Freeman. 1973; p. 202-262.

(10) Sano M, Ernesto C, Thomas RG et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med. 1997 Apr 24;336(17):1216-22

(11) Kaneko S, Wang J, Kaneko M, Yiu G, Hurrell JM, Chitnis T, Khoury SJ, He Z. Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models. J Neurosci. 2006 Sep 20;26(38):9794-804. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed See also: Vitamins fight multiple sclerosis. Orthomolecular Medicine News Service, October 4, 2006.

For More Information:

A complete copy of Dr. Harold D. Foster's What Really Causes Alzheimer's Disease is available in PDF format, free of charge: http://www.hdfoster.com/Foster_Alzheimers.pdf

To access a free archive of peer-reviewed medical journal papers on the safety and efficacy of vitamin therapy: http://orthomolecular.org/library/jom/

Review of nutritional approaches to Alzheimer's Disease: http://www.doctoryourself.com/alzheimer.html

Additional Reading:

Klenner FR. Response of peripheral and central nerve pathology to mega-doses of the vitamin B-complex and other metabolites. Journal of Applied Nutrition, 1973. http://www.tldp.com/issue/11_00/klenner.htm

Morris MC, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Wilson RS, and Scherr PA. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer's disease in a biracial community study. Journal of the American Medical Association, 2002. 287(24), 3230-3237.

Morris MC, Evans DA, Bienias PA, Scherr A, Tangney CC, Hebert LE, Bennett DA, Wilson RS, and Aggarwal N. Dietary Niacin and the Risk of Incident Alzheimer's Disease and of Cognitive Decline. J Neurology, Psychiatry 2004; 75: 1093-1099.

Bobkova NV. The impact of mineral ascorbates on memory loss. Paper presented at the III World Congress on Vitamin C, 2001, Committee for World Health, Victoria, BC, Canada.

Galeev A, Kazakova A, Zherebker E, Dana E, and Dana R. Mineral ascorbates improve memory and cognitive functions in older individuals with pre-Alzheimer's symptoms. Copy of paper given to authors by R. Dana and E. Dana, Committee for World Health, 20331 Lake Forest Drive, Suite C-15, Lake Forest, California 92630, USA.

Bobkova NV, Nesterova IV, Dana E, Nesterov VI, Aleksandrova IIu, Medvinskaia NI, and Samokhia AN (2003). Morpho-functional changes of neurons in temporal cortex in comparison with spatial memory in bulbectomized mice after treatment with minerals and ascorbates. Morfologiia, 123(3), 27-31. [In Russian]

Engelhart MJ, Geerlings MI, Ruitenberg A, van Swieten JC, Hofman A, and Witteman JC (2002). Dietary intake of antioxidants and risk of Alzheimer's disease: Food for thought. Journal of the American Medical Association, 287(24), 3223-3229.

Grant WB. Dietary links to Alzheimer's disease: 1999 update. Journal of Alzheimer's disease, 1999, 1(4,5), 197-201.

Barberger-Gateau P, Letenneur L, Deschamps V, Pérès K, Jean-François Dartigues JF, and Renaud S (2002). Fish, meat, and risk of dementia: Cohort study. British Medical Journal, 325, 932-933.

Vogiatzoglou A, Refsum H, Johnston C, Smith SM, Bradley KM, de Jager C, Budge MM, Smith AD. Vitamin B12 status and rate of brain volume loss in community-dwelling elderly. Neurology. 2008 Sep 9;71(11):826-32.

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Posted in: 2009,Alzheimer's,health news,lithium,natural health news,natural news,niacin,vitamins,vitamins for Alzheimer's