VIOXX Continues to Be Risky

December 13, 2010: Heart risks of Vioxx persist long after drug is stopped

People who thought they were in the clear after they stopped taking the now banned painkiller rofecoxib (Vioxx) might have to think again. The risks of the drug, which was pulled off the market in 2004 after it was linked to heart attacks and strokes, persist even after people stop taking it, according to a study released Monday in the Archives of Internal Medicine.

The findings also serve as a reminder to use caution with related painkillers that are still available, notably celecoxib (Celebrex). Some studies suggest it might pose similar, though less severe, risks to the heart. Other related drugs, such as ibuprofen (Advil and generic) and naproxen (Aleve and generic), might as well. And all of those drugs, called nonsteroidal anti-inflammatories (NSAIDs), can cause dangerous gastrointestinal bleeding and other problems, especially when taken long term. See our advice on when to take an NSAID.

The new study found that seniors with mild cognitive impairment who had taken Vioxx had a higher rate of cardiovascular problems and death up to nearly a year and a half after they stopped taking the drug compared with those who took a placebo. It's unknown whether those risks persist even longer because none of the people in the study were followed past 500 days after they stopped taking Vioxx.
—Steve Mitchell, associate editor, Consumer Reports Best Buy Drugs

Selections from Natural Health News

Vioxx maker Merck drew up hit list

Sep 27, 2009
Dr Fries said in the letter that Merck had been systematically playing down the side effects of Vioxx and said the company's behaviour "seriously impinges on academic freedom". The court was also told a rheumatologist on Merck's ...
Natural Health News: Pfizer hedging its bets? UPDATE
Oct 17, 2008
The Vioxx withdrawal, which triggered an avalanche of lawsuits against Merck, also raised concerns about the safety of other medicines in the same class, called Cox-2 inhibitors. They were heavily touted by their makers as superior to ...
Natural Health News: Drugs Contribute to Dementia, Delirium
Apr 01, 2009
For example, Public Citizen warned consumers about the dangers of Vioxx, ephedra, Baycol and Propulsid years before they were pulled from the market. A partial list of drugs is below. I chose Antihistamines because it is the time of ...
WE TOLD YOU SO
Aug 16, 2006
(Merck, the manufacturer of Fosamax, is currently involved in thousands of lawsuits involving its drug Vioxx which is no longer on the market. Vioxx was pulled after a study revealed that people taking the drug had an increased risk of ...

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Posted in: cardiac arrythmia,heart,VIOXX

Vioxx maker Merck drew up hit list

This representation of corporate culture is just one reason why US healthcare costs are so high. It has nothing to do with helping people be healthy and well, its all about the product at what ever the price.

Interestingly enough a Merck detail rep in Anchorage is know to me to have engaged in a similar deceptive practice while making willful false statements about some help I provided him.

I guess Merck seeks out the unethical and dishonest to fill the ranks of their employees, they'll do what ever it takes to keep their job, or harm someone else, when they know they are lying.

When I think how degraded the health industry has become at the expense of people, I still fondly recall our neighbor from childhood, one of the top MSD executives.

Milanda Rout | April 01, 2009
Article from: The Australian
An international drug company made a hit list of doctors who had to be "neutralised" or discredited because they criticised the anti-arthritis drug the pharmaceutical giant produced.

Staff at US company Merck &Co emailed each other about the list of doctors - mainly researchers and academics - who had been negative about the drug Vioxx or Merck and a recommended course of action.

IN-DEPTH COVERAGE: The Vioxx Trial

The email, which came out in the Federal Court in Melbourne yesterday as part of a class action against the drug company, included the words "neutralise", "neutralised" or "discredit" against some of the doctors' names.

It is also alleged the company used intimidation tactics against critical researchers, including dropping hints it would stop funding to institutions and claims it interfered with academic appointments.

"We may need to seek them out and destroy them where they live," a Merck employee wrote, according to an email excerpt read to the court by Julian Burnside QC, acting for the plaintiff.

Merck & Co and its Australian subsidiary, Merck, Sharpe and Dohme, are being sued for compensation by more than 1000 Australians, who claim they suffered heart attacks or strokes as a result of Vioxx.

The drug was launched in 1999 and at its height of popularity was used by 80 million people worldwide because it did not cause stomach problems as did traditional anti-inflammatory drugs.

It was voluntarily withdrawn from sale in 2004 after concerns were raised that it caused heart attacks and strokes and a clinical trial testing these potential side affects was aborted for safety reasons.

Lead plaintiff Graeme Peterson, 58, claims the drug caused him to have a heart attack in 2003 after he took it for back pain and arthritis every day from May 2001.

Merck last year settled thousands of lawsuits in the US over the effects of Vioxx for $US4.85billion ($7.14 billion) but made no admission of guilt.

The company is fighting the class action in Australia.

The Federal Court was told yesterday that Merck wanted to gain the backing of researchers and doctors - or "opinion leaders" - in the fields of arthritis to help promote the drug to medical professionals when it was launched in 1999.

Mr Burnside said internal emails in April 1999 from Merck staff showed the company was not happy with what some researchers and doctors were saying about the drug.

"It gives you the dark side of the use of key opinion leaders and thought leaders ... if (they) say things you don't like to hear, you have to neutralise them," he said. "It does suggest a certain culture within the organisation about how to deal with your opponents and those who disagree with you."

The court was told that James Fries, professor of medicine at Stanford University, wrote to the then Merck head Ray Gilmartin in October 2000 to complain about the treatment of some of his researchers who had criticised the drug.

"Even worse were allegations of Merck damage control by intimidation," he wrote, according to Mr Burnside.

"This has happened to at least eight (clinical) investigators ... I suppose I was mildly threatened myself but I never have spoken or written on these issues."

Mr Burnside told the court Dr Fries went on to describe instances of intimidation, including one colleague who thought his academic appointment had been jeopardised and another who received phone calls alleging "anti-Merck" bias.

Dr Fries said in the letter that Merck had been systematically playing down the side effects of Vioxx and said the company's behaviour "seriously impinges on academic freedom". The court was also told a rheumatologist on Merck's Australian arthritis advisory board was angry he did not find out about Merck's decision to withdraw Vioxx until an ABC journalist rang to tell him. Mr Burnside said James Bertouch wrote to other members of the board saying he was "extremely disillusioned" with the company.

"In every possible way the company exerted itself to present the impression to the world at large that Vioxx did not provide any increased cardio risk ... when (a) it probably would and (b) it probably did," he wrote, according to Mr Burnside.

Peter Garling, acting for Merck, accused Mr Peterson of not taking the drug Vioxx in the months leading up to his heart attack in December 2003.

He said Pharmaceutical Benefits Scheme figures showed he did not fill a Vioxx prescription for the drug in the two months before his heart attack.

Mr Garling put to Mr Peterson during his cross-examination that this was because he had retired from his job as a safety consultant and therefore he did not need to take Vioxx because his back pain lessened.

Mr Peterson denied this meant he was not taking the drug.

"No, I wouldn't accept that at all," he said. "I can remember taking Vioxx regularly."

The trial, before Justice Chris Jessop, continues.

Further reading on Corporations -

When I was first in college in the 60s, the popular book to read was "The Organization Man", now it seems that this is a replacement.
Gangs of America: The Rise of Corporate Power and the Disabling of Democracy by Ted Nace

"A good book to read is called: "The Gangs of America"; which chronicles how with about one dozen supreme court cases (because the northeastern railroads payed off congress to pack the Supreme Court with pro corporate constitutional personhood rights justices) that have given corporations with the "myth" of constitutional personhood....the second american revolution's central causes are twofold: the first being the federal reserve controlling our politics; business and quality of life through inflation and deflation and control of the issuance of money.....the second cause will be the corporate oligarchy and the mythic "rights" that have been fraudulently bestowed on the corporate entity in our nation beginning in the 1870's....if you don't believe me; purchase and read the book that I mentioned in the beginning of this paragraph....and make up your own mind....if we all work together we can get back to a nation where most of the American population is self employed; or work for small locally owned businesses; a nation where we are once again self reliant; and we can in this nation place the corporate charter model and the anti democratic and anti republican tendencies of it into the dust bin of history forever...."

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Posted in: ethics,Greg Sipe,Merck,natural health news,VIOXX