Where are the Niacin Studies for Schizophrenia?

from November 2009, timely today in regard to the discussion about psychiatry currently in the news.

Natural Mental Health

UPDATE 12/21 - Food Sources of Niacin (B3)

UPDATE: 12/18 - If you have been a proponent of natural mental health you would already have known that omega 3 EFAs have been an effective help to many who live with several mental health issues.

BETHESDA, Md., Dec. 18 (UPI) -- Deficiencies in omega-3 fatty acids may be a factor in mental illnesses, U.S. researchers suggest.

The study, published in Behavioral Neuroscience, named two omega-3 fatty acids -- docosahexaenoic acid and eicosapentaenoic acid -- as key to maintaining a nervous system capable of avoiding sensory overload.

The researchers suggest low omega-3 may be linked to the information-processing problems found in people with afflictions of the nervous system including schizophrenia and bipolar, obsessive-compulsive, attention-deficit hyperactivity disorders.

The researchers looked at nervous system function in the offspring of four groups of pregnant mice that had been fed different diets with no or varying types and amounts of omega-3s. Only the mice raised on the two omega-3 fatty acids showed normal, adaptive sensorimotor nervous responses that did not result in the animals being perpetually startled and easily overwhelmed by sensory stimuli.

"It is an uphill battle now to reverse the message that 'fats are bad,' and to increase omega-3 fats in our diet," study leader Norman Salem Jr. of the National Institute on Alcohol Abuse and Alcoholism in Bethesda said in a statement.

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Travelling back some 50 or more years ago there were some members of the medical profession who took a totally different look at mental health issues.  Instead of fluoride based anti-psychotics, these courageous fellows relied on nutritional supplementation and effectively treated thousands of people diagnosed as schizophrenic.

And to make it all the more respectable, numerous scientific reports were issued on this care that came to be known as orthomolecular medicine.

And you might wonder why PubMed fails to include the orthomolecular journal so you might be more able to find related data.

Schizophrenia and Schizoaffective Disorders
Double blind controlled therapeutic trials in Saskatchewan in 1952 showed that adding vitamin B-3 to the treatment then available, which was electro convulsive therapy, doubled the recovery rate. From this start, and corroborated by a large number of clinical studies and by one double blind corroborative study that was sponsored by National Institute of Mental Health, Washington, this early treatment has been refined and expanded. There are no negative studies. It now includes examination of the diet for possible food allergies; includes using optimum doses of vitamin B-3, which range from 3 to 12 or more grams daily; includes the use of vitamin C as an important antioxidant and other vitamins if needed, plus the best medication. As patients respond, the doses of medication and the nutrients are adjusted until the optimum doses of all nutrients and drugs is achieved. This treatment should be under medical control.

Nutrients Most Commonly Used For Schizophrenia and Schizo-Affective Disorders (under medical supervision):



* Vitamin B-3

* Vitamin C

* Vitamin B-6

* Zinc

* Vitamin B complex

* Selenium

Mood Disorders: Anxiety, Bipolar or Depression -
The following nutrients are helpful in controlling mood disorders (under medical supervision):


* Niacinamide

* B complex

* Vitamin C

* Folic acid

* Vitamin D

* Vitamin B-6
* Zinc citrate

* Essential fatty acids


In contrast to anti depressant medication I have not yet seen the type of warning issued by Professor Lana Watkins PhD, Duke University, who told the Annual meeting of the American Psychosomatic Society held in Denver, March 4, 2006, that current anti depressants increased the risk of dying from heart disease by 55 percent.

"Orthomolecular treatment does not lend itself to rapid drug-like control of symptoms, but patients get well to a degree not seen by tranquilizer therapists who believe orthomolecular therapists are prone to exaggeration. Those who've seen the results are astonished." 
---Abram Hoffer, M.D., Ph.D., 1917-2009

Read: http://naturalhealthnews.blogspot.com/2009/08/arthritis-drugs-pose-cancer-risk.html

FDA Okays New Antipsychotic for Schizophrenia, Bipolar Disorder
By Cole Petrochko, Staff Writer, MedPage Today, August 14, 2009

WASHINGTON -- The FDA approved the atypical antipsychotic asenapine (Saphris) for schizophrenia and bipolar disorder in adults, making it the first psychotropic drug to gain initial approval for both conditions.

The drug is indicated for first-line use in acute treatment of schizophrenia and of manic or mixed episodes in bipolar I disorder, with or without psychotic features.

FDA approval was based on data from more than 3,000 patients showing statistically significant efficacy versus placebo in acute schizophrenia trials and statistically significant reduction of bipolar mania symptoms versus placebo.

The drug showed signs of treating negative schizophrenia symptoms better than risperidone (Risperdal) in early clinical trials, but the advantage was not subsequently confirmed against olanzapine (Zyprexa, Zydis). (See APA: New Drug No Better for Negative Schizophrenia Symptoms)

Like other atypical antipsychotics, asenapine's side effects include sedation, weight gain, tardive dyskinesia, and diabetes risks. However, a clinical trial showed that asenapine's rate of weight gain was significantly lower than that experienced with olanzapine, a similar antipsychotic.

Atypical antipsychotics also show an increased likelihood of death in elderly patients treated for dementia-related psychosis.

The tablets are available in five and 10 mg doses and should be taken twice daily.

Manufacturer Schering-Plough said it plans to make the drug available in the fourth quarter of 2009.

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Posted in: antipsychotics,atypical antipsychotics,B3,food source of B3,food source of niacin,natural mental health,niacin,niacinamide,Omega 3,orthomolecular medicine,schizophrenia,vitamins

Gotta LUV Us Orthomolecular Types

New Resources on Nutritional Therapeutics
Orthomolecular, Online . . . and Free of Charge

(OMNS Dec 3, 2010) Many readers wanting to learn more about nutritional therapeutics have sent in email requests for additional information. While the Orthomolecular Medicine News Service cannot answer these individually, we offer in this issue a directory of links to online resources that may prove valuable.
Vitamin C and Cancer: What can we conclude?
Comments by Andrew W. Saul, Michael J. Gonzalez, Jorge R. Miranda-Massari, Jorge Duconge, and Fernando Cabanillas http://prhsj.rcm.upr.edu/index.php/prhsj/article/viewFile/546/384
Details of the Intravenous Vitamin C Treatment Protocol of Hugh D. Riordan, M.D.
http://www.doctoryourself.com/RiordanIVC.pdf and or http://www.riordanclinic.org/research/vitaminc/protocol.shtml
Access to Specifics of Nutritional Treatment Protocols
http://orthomolecular.org/resources/omns/v06n25.shtml
Journal of Orthomolecular Medicine Online Archive
http://orthomolecular.org/library/jom/index.shtml
41 years of JOM are now available as full-text pdf downloads, free of charge.
Orthomolecular Medicine News Service Online Archive
http://orthomolecular.org/resources/omns/index.shtml
Online access to nearly 100 issues.
Directories for Finding a Nutritionally-Minded Doctor
http://orthomolecular.org/resources/omns/v06n09.shtml
Archive of Natural Health Articles, in German
[Archiv der deutschsprachigen Artikel, auf DoctorYourself.com]
http://www.doctoryourself.com/DeutschIndizieren.html
This project is being updated and expanded almost daily. Volunteer translators are welcome.
Orthomolecular Medicine for India
http://en.wikipedia.org/wiki/Orthomolecular_Medicine_for_India
A new Wikipedia page devoted to the benefits of nutritional medicine for emerging nations.
Dr. Frederick R. Klenner's Clinical Guide to the Use of Vitamin C is posted in its entirety at http://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
The complete text of Irwin Stone's book The Healing Factor is posted for free reading at http://vitamincfoundation.org/stone/
A very large number of free-access, full-text papers on curing illness with vitamin C are posted http://www.seanet.com/~alexs/ascorbate .
For more information on Vitamin C:
http://www.vitamincfoundation.org/
http://www.cforyourself.com
Read Linus Pauling's complete 1968 paper on vitamin therapy at http://www.orthomed.org/home/pauling2.html
A 1974 Pauling paper on the same subject is posted at http://www.orthomed.org/home/pauling.html
Linus Pauling and colleagues show how vitamin C and the amino acid lysine may prevent and cure atherosclerosis. http://www.internetwks.com/pauling/
Heart Health
http://www.health-heart.org/aFullSitePDF.pdf is a free pdf download of a full-color book on preventing and reversing heart disease nutritionally.
Dr. Abram Hoffer explains why there is so much opposition to vitamin therapy at http://www.internetwks.com/pauling/hoffer.html
Feingold Association
"Numerous studies show that certain synthetic food additives can have serious learning, behavior, and/or health effects for sensitive people." Learn what to do at http://www.feingold.org/research.php and http://www.feingold.org/newsletters.php Free email newsletter available at http://www.feingold.org/ON.html .
There are doctors supportive of vegetarianism, and here they are: The Physicians' Committee for Responsible Medicine http://www.pcrm.org . Free download of their "New Four Food Groups at http://www.pcrm.org/health/veginfo/vsk/4foodgroups.pdf

Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org
The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

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Posted in: orthomolecular medicine

Good News About Vitamins

That TV Doctor Lisa Masterson would just love you to believe her propaganda force fed to medical students and reinforced by mainstream media that all you need for good nutrition is a healthy diet. I wonder if she ever looked in to nutrient depletion caused by the drugs she prescribes and explains to her patients that they just don't need to take supplements to counter these losses.

You've also heard much of the same diatribes on ABC News with Diane Sawyer.

Registered Dietitians feed you the same pablum, but of course all this is spoon fed to them via Big Ag and USDA.

In today's world of corporate agriculture and its impact on food, especially considering the long distance things are sent to market, little in the way of nutrients are left by the time you get it home and prepared.

Worse are the frozen dinners used by a very high percentage of women, especially younger age groups, as reported in Nutrition Business Journal.

It does pay to eat organic and to use supplements, especially if you are dealing with disease and chronic health problems.

FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, May 25, 2010

Vitamin E Research Ignored by Major News Media Coast-to-Coast Censorship
If you think Medline and Wikipedia are biased, take a look through your newspapers and magazines. For example, have you noticed how the news media are quick to publish negative allegations about vitamin E, but slow to present the positive side?

Here's a check to see if this is so: Have you seen any articles on the effectiveness of vitamin E therapy reported in your daily newspaper?

* Increasing vitamin E prevents COPD [Chronic obstructive pulmonary disease, emphysema, chronic bronchitis] (Agler AH et al. Randomized vitamin E supplementation and risk of chronic lung disease (CLD) in the Women's Health Study. American Thoracic Society 2010 International Conference, May 18, 2010.) Summary at http://www.thoracic.org/newsroom/press-releases/conference/articles/2010/vitamine-e.pdf

* 800 IU vitamin E per day is a successful treatment for fatty liver disease. (Sanyal AJ, Chalasani N, Kowdley KV et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010 May 6;362(18):1675-85.) http://www.ncbi.nlm.nih.gov/pubmed/20427778

* Alzheimer's patients who take 2,000 IU of vitamin E per day live longer. (Pavlik VN, Doody RS, Rountree SD, Darby EJ. Vitamin E use is associated with improved survival in an Alzheimer's disease cohort. Dement Geriatr Cogn Disord. 2009;28(6):536-40.) Summary at http://www.associatedcontent.com/article/719537/alzheimers_patients_who_take_vitamin.html?cat=5

See also: Grundman M. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr. 2000 Feb;71(2):630S-636S. Free access to full text at http://www.ajcn.org/cgi/content/full/71/2/630s )

* Taking 300 IU vitamin E per day reduces lung cancer by 61%. (Mahabir S, Schendel K, Dong YQ et al. Dietary alpha-, beta-, gamma- and delta-tocopherols in lung cancer risk. Int J Cancer. 2008 Sep 1;123(5):1173-80.) http://www.ncbi.nlm.nih.gov/pubmed/18546288

* 400 to 800 IU of vitamin E daily reduces risk of heart attack by 77%. (Stephens NG et al. Randomized controlled trial of vitamin E in patients with coronary artery disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet, March 23, 1996; 347:781-786.) http://www.ncbi.nlm.nih.gov/pubmed/8622332

* 400 IU of Vitamin E per day reduces epileptic seizures in children by more than 60%. (Ogunmekan AO, Hwang PA. A randomized, double-blind, placebo-controlled, clinical trial of D-alpha-tocopheryl acetate [vitamin E], as add-on therapy, for epilepsy in children. Epilepsia. 1989 Jan-Feb; 30(1):84-9.) http://www.ncbi.nlm.nih.gov/pubmed/2643513

Such effective quantities of vitamin E positively cannot be obtained from diet alone. 400 IU is over 25 times the adult US RDA for vitamin E. Is that a lot, or is the government recommendation too low?

Have you seen any article in any major newspaper or magazine pushing to raise the RDA?

This might be a good time for them to do so: they need the readership. The New York Times is over a billion dollars in debt. (1) Newsweek, having lost $40 million in just the last two years, is now for sale. (2) This could explain why they are so anti-supplement (and pro-pharmaceutical), since they appear to depend on drug advertising money to try to keep afloat.

The Orthomolecular Medicine News Service takes no advertising from anybody and is free of charge. It is not in debt, and it is not for sale. OMNS will continue to announce and advocate vitamin therapy, because it works.

If you would like to join in, please consider writing a pro-vitamin letter to the editor of your local newspaper or favorite magazine. OMNS would welcome a copy of your correspondence.

For More Information:

These doctors say, Raise the RDA now: http://orthomolecular.org/resources/omns/v03n10.shtml

Specifically in regard to vitamin E: http://www.doctoryourself.com/evitamin.htm

For vitamin C: http://orthomolecular.org/resources/omns/v06n08.shtml

For vitamin D: http://orthomolecular.org/resources/omns/v06n10.shtml

References:

(1) http://www.observer.com/2009/media/new-york-times-company-quarterly-conference-call-total-revenue-down-186-percent-debt-13-b

(2) http://www.investorguide.com/article/6411/washington-post-attempts-to-sell-newsweek-magazine-wpo/

Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org. The peer-reviewed Orthomolecular Medicine News Service is a non-profit and non-commercial informational resource.

And if this isn't enough a new report shows 

Anti-aging supplements better sooner

GAINESVILLE, Fla., May 25 (UPI) -- U.S. researchers suggest a study in rats indicates anti-aging supplements may be better taken sooner rather than later.
Researchers at the University of Florida's Institute on Aging in Gainesville say a neutraceutical -- a pharmaceutical product that has nutritional properties -- taken before very old age may benefit muscles.
Senior author Christiaan Leeuwenburgh and colleagues measured grip strength in rats fed for six weeks with a mixture of co-enzyme Q10, creatine and ginseng commercially available and marketed for relieving chronic fatigue and preventing muscle aging. The rats were middle-aged -- 21 months old, equivalent to humans ages 50-65, and late-middle-aged -- 29 months old in rats, equivalent to humans ages 65-80.
The study in rats, published in the journal PLoS One, finds supplementation was linked to a muscle improvement of 12 percent in middle-aged rats. However, supplementation brought no improvement in the older group of rats.
"I think it is important for people to focus on good nutrition, but for those of advanced age who are running out of energy and not moving much, we're trying to find a supplement mixture that can help improve their quality of life," Leeuwenburgh says in a statement.

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Posted in: ABC News vitamins,Diane Sawyer,OMNS,orthomolecular medicine,vitamins promote health

More Evidence of The Circle Game: Restricting Access

Nutritional Medicine is Orthomolecular Medicine

Want to be a MEDLINE Information Censor?  The National Library of Medicine Needs You!

(OMNS, Jan 28, 2010) Would you like to dictate what nutritional research people may or may not access? Why not join the NLM's Literature Selection Technical Review Committee?

We think a good preparatory step is to take the Medline Censorship Aptitude Test (MED-CENT).

Not to worry; it's multiple choice.

First question: Which of the following research papers is NOT indexed by the National Library of Medicine's Medline?

A) Olfactory responses and field attraction of mosquitoes to volatiles from Limburger cheese and human foot odor. (J Vector Ecol, 1998)
B) Heated socks maintain toe temperature but not always skin blood flow as mean skin temperature falls. (Aviat Space Environ Med, 2003)
C) Jefferson JW, Thompson TD. Rhinotillexomania (nose-picking): psychiatric disorder or habit? (J Clin Psychiatry, 1995)
D) Pauling L, Rath M. An orthomolecular theory of human health and disease. (J Orthomolecular Medicine, 1991)

Answer: Only choice "D" is not available on Medline. The others most certainly are. Search each one and see for yourself at http://www.ncbi.nlm.nih.gov/pubmed/ or http://www.ncbi.nlm.nih.gov/sites/entrez

Let's try another: Which of these studies is NOT indexed by Medline?

A) Psychophysiological responding during script-driven imagery in people reporting abduction by space aliens. (Psychol Sci, 2004)
B) The eyebrow frown: a salient social signal. (Emotion, 2002)
C) Staring at one side of the face increases blood flow on that side of the face. (Psychophysiology, 2004)
D) Rath M, Pauling L. Solution to the puzzle of human cardiovascular disease: Its primary cause is ascorbate deficiency leading to the deposition of lipoprotein(a) and fibrinogen/fibrin in the vascular wall. (J Orthomolecular Medicine, 1991)

Answer: "D" is not on Medline. All the rest are.

Ready? Select the study below that is NOT on Medline:

A) Espresso kiosks can be profitable addition to hospital foodservice. (Health Foodserv Mag, 2000)
B) Espresso maker's wrist. (West J Med, 1990)
C) Characterization of particles in cream cheese. (J Dairy Sci, 2004)
D) Rath M, Pauling L. Case Report: Lysine/ascorbate related amelioration of angina pectoris. (J Orthomolecular Medicine, 1991)

Yes, the study that Medline does not think is important enough for you to see is choice "D". The others are all indexed online by NLM at taxpayer expense.

Next:

A) The Easter bunny in October: is it disguised as a duck? (Percept Mot Skills, 1993)
B) Increasing the portion size of a packaged snack increases energy intake in men and women. (Appetite, 2004)
C) A piece of my mind. Reflections while listening to the Glazunov Saxophone Concerto. (JAMA, 2003)
D) Rath M, Pauling L. Apoprotein(a) is an adhesive protein. (J Orthomolecular Medicine, 1991)

You guessed it: "D" is not on Medline.

One last chance, now:

A) How dogs navigate to catch Frisbees. (Psychol. Sci, 2004)
B) Effect on tipping of barman drawing a sun on the bottom of customers' checks. (Psychol Rep, 2000)
C) An objective evaluation of the waterproofing qualities, ease of insertion and comfort of commonly available earplugs. (Clin Otolaryngol, 2004)
D) Hoffer A, Pauling L. Hardin Jones biostatistical analysis of mortality data for a second set of cohorts of cancer patients with a large fraction surviving at the termination of the study and a comparison of survival times of cancer patients receiving large regular oral doses of vitamin C and other nutrients with similar patients not receiving these doses. (J Orthomolecular Medicine, 1993)

Choice "D" is not indexed by Medline. The others are. Yes, they really are. Just type in the title at http://www.ncbi.nlm.nih.gov/pubmed/ or http://www.ncbi.nlm.nih.gov/sites/entrez
If you got all the above items right, you are well qualified to become a member of the NLM's Literature Selection Technical Review Committee, because you can discern what research should and should not be available to the public.

Censoring Linus Pauling

If you look carefully at the first four questions, you will see that four of Linus Pauling's papers appeared in the Journal of Orthomolecular Medicine in just one year. That year was 1991. Two years after this, JOM was reviewed by the National Library of Medicine's Literature Selection Technical Review Committee. NLM uses a point scale of zero to 5, with five being the highest recommendation for indexing, and zero being the lowest. On March 4, 1993, the Journal of Orthomolecular Medicine received a "0.0" score.

One cannot escape the significance of such judgment. After all, "0.0" is not merely a low mark. "0.0" represents an absolute dearth of merit. And "zero point zero" states it so flatly as to leave no room for alternate interpretations.
To this day, after additional reviews, Medline still does not include the Journal of Orthomolecular Medicine.
To read the Linus Pauling papers that Medline decided rate a "0.0": http://orthomolecular.org/library/jom/1991/toc3.shtml and http://orthomolecular.org/library/jom/1993/toc3.shtml

For free online access to 600 more full-text papers from the Journal of Orthomolecular Medicine: http://orthomolecular.org/library/jom/

To personally thank your National Library of Medicine for keeping all this information from the taxpayer:
Ms Betsy Humphreys, Deputy Director, NLM
email: betsy.humphreys@nih.gov or betsy_humphreys@nlm.nih.gov
phone: 301-496-6661

You can also call the NLM Customer Service desk at 1-888-FIND-NLM (1-888-346-3656). Remember to be polite, because, after all, they are the "World's Largest Medical Library." http://www.nlm.nih.gov/nlmhome.html

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Posted in: censorship,Medline,orthomolecular medicine