Showing posts with label drug interactions. Show all posts
Showing posts with label drug interactions. Show all posts

Saturday, May 29, 2010

Avoiding Drug Side Effects

"A study linking drug side effects and emergency room admissions found that a large number of Americans -- as many as 700,000 annually -- land in the hospital from taking medications. But the good news is that there are precautions you can take to avoid some of the worst adverse drug events detailed in the study."

In this report, which is helpful to some extent, item number 1 is 
Ask your doctor about side effects.
Yes, you should ask anytime any provider offers you a prescription, but don't forget that it is the provider's responsibility to thoroughly inform you, so that you should not have to ask.
You are also supposed to be told of any drug interaction that may occur from a combination of drugs you may be getting from your provider.
Too often this is ignored, and it places your health at risk.
Item 5 has real value, but my suggestion is to do this at least once every six months, even better to do it quarterly.
If you suspect a side-effect, even if it is one you were not informed of, call your provider and pharmacist immediately.
Health Forensics offers drug nutrient depletion information and interaction review services.

Tuesday, February 2, 2010

Call to end exclusion of elderly from drug trials

This news story caught my eye because I have become concerned about this very issue over the past six or seven years. In my way of thinking it is important to set up specific drug trials not just for Elders but for children and women too.

In 2003 my mother suffered a closed head injury, and as a result of her fall and the TBI she developed expressive aphasia.

Expressive aphasia is condition  and an acquired disorder of language due to brain damage. Most aphasias and related disorders are due to stroke, head injury, cerebral tumors, or degenerative diseases.  People may lose the ability to produce speech, to comprehend speech, to repeat, and to hear and read words in many nuanced ways. Language difficulties can also be affected by pharmaceutical drugs often over used in faculties that care for Elders.

Speech and language therapy is the mainstay of care for people with with aphasia. The timing and nature of the interventions for aphasia vary widely. Blinded studies are limited, and recovery of many degrees is expected.  Studies also indicate that speech and language therapy does improve clinical outcomes in aphasia, but individualized programs are important. 

The potential for functional recovery from primarily expressive aphasia after stroke is excellent. A neurologist should be key in evaluation and care, as well as speech therapy.

After her injury, my mother was placed in a 5 Star facility in Naples, Florida.  She was loaded up with an over abundance of psychotropic drugs, including  Zyprexa, yet did not have a neurologist or speech therapy prescribed.

Zyprexa is questionable for the elderly, especially for use in elderly women, and it can precipitate diabetes.  The case in point is that regardless of the number of drugs prescribed, and failure of the center to evaluate the drugs for interaction, no one except me questioned the use of this drug in my mother's care.  Zyprexa has an unusually difficult time being excreted by older women and as a result has a longer half-life.

Another drug being given to my mother, not prescribed by a neurologist, was Neurontin, and it is implicated in the development of impaired speech. And yet another one of the several SSRIs perscribed has a known side effect of suicidal thinking.  My mother tried to jump out of a window.  The outcome: more drugs to sedate her further.

The house psychiatrist diagnosed my mother as depressed.  Yet when I asked how he diagnosed her with the aphasia, he could not answer.  He just prescribed more drugs.

I contacted a colleague in the pharmaceutical research section dealing with psychotropic durgs at the FDA for an opinion on the list of drugs prescribed to my mother.  He was shocked, and especially noted the severe issues indicated by the drug interaction profile.

The care center supplying pharmacy never conducted a thorough interaction profile. 
The attending GP, a whining DO from a near by town, most likely interested in the Medicare reimbursement more than my mother's condition, whined to my brother after I talked with him, saying he did not like the questions I was asking.

The director of nursing threatened forced relocation if my mother was taken off any of the drugs.  Since the bill went to Medicare I am sure reimbursement was more the concern than my mother's well being.  And of course there is the issue of staff convenience.

Well, my mother died last summer.  She won't be forced now to take any more drugs, but for six years which must have been agonizing for her, she was over drugged and could not communicate.

My little brother, who held POA, a player in the insurance/finance business, made absolutely no effort to see that my mother was taken to a nationally recognized neurologist in Naples.  Nor would acknowledge my concerns over the drugs and her treatment.  He failed to get her even the most clearly established care for  the aphasia, but was concerned over the cost of the drugs.

He also failed to tell the care center that my mother had a daughter, and didn't make any effort to contact me about this incident until three months after it happened.
Read the complete areticle here - http://news.bbc.co.uk/2/hi/health/8487509.stm

Friday, July 17, 2009

Dangerous Drug Pairs

It is hard to say exactly why this problem is so prevalent but it is one I have addressed over the years based on my experience as a nurse practitioner.

During all of the required and on-going courses I completed in pharmacology it was always stressed to address the required responsibility of knowing the risks and benefits of a pharmaceutical agent, including interaction risk, and educate your client with this information.

As you can see, research has proven my theory that little or none of this occurs.

When you retain our services, and you are using prescribed pharmaceuticals, one of the first tasks I address is the completion of a drug interaction profile.

You would be very surprised at the numerous and serious drug/health issues that I am able to identify.

If you'd like to engage our consultation services you can learn more here...

Pharmacy Research Shows Prescribers Miss Potentially Dangerous Drug Pairs

ScienceDaily (2009-07-16) -- Medication prescribers correctly identified fewer than half of drug pairs with potentially dangerous drug-drug interactions. The researchers mailed a questionnaire to 12,500 U.S. prescribers who were selected based on a history of prescribing drugs associated with known potential for drug-drug interaction. Prescribers were primarily physicians, physicians' assistants and nurse practitioners. ... > read full article


And perhaps this is profit driven..

Tuesday, March 3, 2009

Plavix and Nexium Combo Nixed

UPDATE: A 2008 Report on PPI / GERD drugs
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ORIGINALLY POSTED Nov, 2008

Addressing stomach acid and blood thinning are two things that can be treated effectively with natural products including herbs and/or supplements.

Natural treatment is much less costly and won't make millions or billions for the drug companies, and it won't cause gastric bleeding or silent bleeding because of "thin" blood or irritation of the mucosal lining of the stomach or elsewhere.

I don't get the logic behind taking a drug if you know the risk will be gastric ulcers. I don't get why a drug is even prescribed when you know you have to prescribe another drug to try to offset a side effect of the first drug.

I think it would be great if roulette was removed from medical guessing.

Serious side effects of Plavix include bleeding and low white blood cell counts or thrombotic thrombocytopenic purpura (TTP - low platelet counts with spontaneous bleeding and clotting). It sells for about $1.50/pill.

Of course we know how horrified doctors are over Vitamin E because it might cause blood "thinning". Be this at it may, high quality, non-soy vitamin E is an effective natural agent that does protect you from cardiovascular insults. It keeps your blood cells from aggregating and is protective against colon cancer. Vitamin E also helps oxygen cross the alveolar membrane in the lungs and eases menopausal symptoms.

Serious side effects of Nexium may include poor protein digestion, impaired liver detoxification and possibly cancer from long term use. It runs about $1/pill or less.

There are effective natural methods to reduce the 'heartburn' side effects of Plavix without reverting to another pharmaceutical leading to a disastrous drug interaction situation.

See: Healthy Suggestion
Concerns on mixing Plavix, heartburn drugs
By AP Business Writers Matthew Perrone And Marley Seaman

NEW YORK – Stent patients who take the blood thinner Plavix along with certain heartburn drugs may face a greater risk of heart attack, stroke and other dangerous events, according to a study released Tuesday.

Researchers found that patients who were taking Plavix with popular prescription heartburn drugs, including AstraZeneca PLC's Nexium, were significantly more likely to be hospitalized for a heart attack, stroke, chest pain or a coronary artery bypass operation than those who took Plavix alone.

The study followed more than 14,000 patients from 2005 to 2006 in a database kept by pharmacy benefits manager Medco Health Solutions Inc.

Nexium and other proton pump inhibitors, like Wyeth's Protonix, are used to treat chronic heartburn, in which stomach acids come back up the esophagus, causing pain and inflammation. Doctors frequently prescribe these drugs to patients on Plavix because the blood thinner has been linked to a higher risk of ulcers.

Medco said 40 percent of patients in its study were taking the prescription heartburn medications. The company's chief medical officer, Robert Epstein, said that if over-the-counter medications like AstraZeneca's Prilosec were included, the percentage would likely be even higher.

Epstein said heartburn drugs could interfere with a liver enzyme needed to process Plavix, neutralizing its effects.

He stressed that patients should not stop taking Plavix or heartburn drugs, particularly if they have a history of stomach problems.

"But if you're a person who's otherwise healthy taking Plavix, you might want to consider calling your doctor and asking, 'Do I need really need this' or 'Do I need it every day?' " Epstein said in an interview. "There are ways to look at this question now that we wouldn't have thought about previously."

Bristol-Myers also urged patients to talk with their doctor before taking action and questioned Medco's approach.

"While we are still reviewing the data, in general, retrospective analyses — in contrast to randomized clinical trials — are more subject to confounding factors," said spokesman Ken Dominski.

Academics at the the American Heart Association's annual meeting in New Orleans, where the data was presented, had similar concerns.

Dr. Robert Harrington of Duke University said that without a rigorous study comparing patients with similar health profiles "you cannot assume that the groups are balanced" and the results are real rather than a fluke.

For example, he said, people taking proton pump inhibitors may also have other health problems that skew their risk for heart disease.

"I would not change practice based on these data," said Harrington, who led an American College of Cardiology panel that last month said it was reasonable for doctors to prescribe these two drugs together.

All patients in the Medco study had been implanted with a stent, or a wire-mesh tube used to prop open arteries after they have been cleared of plaque. The study tracked whether they had been hospitalized for the heart and circulatory problems within a year of the stent being implanted.

In patients who had not suffered a previous heart attack, 32.5 percent patients who took Plavix and a heartburn drug experienced one of the severe events within a year of their stent surgery. Those events were seen in just 21.2 percent of patients who took only Plavix.

In patients who had suffered a previous heart attack, 39.8 percent of patients experienced the severe events within a year. In patients who did not take the heartburn drugs, only 26.2 percent did.

Plavix, or clopidogrel, is the second best-selling drug in the world, with global sales of $7.3 billion in 2007. It is marketed by Bristol-Myers Squibb Co. and Sanofi-Aventis SA.

Heartburn drugs were the fourth best-selling class of drugs last year, with sales of $25.6 billion, according to IMS Health.

Shares of Bristol-Myers Squibb Co. fell 34 cents Tuesday to close at $20.04. Shares of Paris-based Sanofi-Aventis rose 5 cents to $30.02.

AP Medical Writer Marilyn Marchione contributed to this report from New Orleans.

 
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