Showing posts with label immune suppression. Show all posts
Showing posts with label immune suppression. Show all posts

Wednesday, August 12, 2009

Immune Supression for Osteoporosis?

UPDATE: August 25 - Feedback on bisphosphonate drugs which contain fluoride, crumbling bones right before your eyes.
I am a femur-fracture survivor...bilateral. The right leg broke in March, the left one in July, 2009. I also suffered a compression fracture at L1 in May.

I was given Fosamax 10 years ago as a preventive measure. Now I am worse than I would have been 20 years down the road. I cannot begin to tell you that there are women breaking a leg everyday! And they do not know why. It was through the fact, that the orthopaedic doctor who took my emergency case on the first leg, had just received some information about the bilateral fractures. If you held my x-ray up against several other womens, you could not tell us apart!

I hope you continue to write and correspond about this important subject. My life has been taken away from me in a way that I never dreamed would happen.

-----------------------------------------------------------------------

These two articles arrived this morning in the same newsletter. I thought it interesting because I had just posted on saturated fat and mentioned how it is necessary to help make Vitamin D work.

Then there's the article about Vitamin D that arrived earlier in the day. There must be a message here.

Of course this is madness to me because there is no consideration of what natural approaches might be more effective and less expensive that a drug that the FDA now is worried about it suppressing immunity.

There's weight bearing exercise, even if you have to so it sitting. And there's Vitamin K, another fat soluble vitamin. Nettle can help too because it is a very potent cytokine reducer (what the TNF drugs do) without suppressing your immune system.

This drug is very much like the Rheumatoid Arthritis drugs, RA is often connected to wheat, gluten and gliaden allergy. Perhaps a RAST test might be a better place to start.
FDA Questions Denosumab Safety in Advisory Meeting Documents
FDA staff has expressed concerns that denosumab, the investigational biologic drug for osteoporosis, may increase risk of serious infections through its activity against an important immune system modulator. The agency believes the drug --... full story http://www.medpagetoday.com/ProductAlert/Prescriptions/tb/15486

Denosumab a Winner in Phase III Osteoporosis Trials
An investigational biologic drug for osteoporosis increased bone density and reduced fractures in men and women in two placebo-controlled trials. Three years of treatment with denosumab reduced radiographic spine fractures more than two-thirds in the... full story http://www.medpagetoday.com/Endocrinology/Osteoporosis/tb/15474

Related to the issue of osteoporosis and immune suppression is this information about fluoride based antibiotics. These drugs also increase risk of tendon rupture, interfere with proper thyroid function, as well as encourage brittle and weaker bones.

Wide Use of Fluoroquinolones Raises Fear of TB Resistance
The widespread use of fluoroquinolone antibiotics may be creating strains of tuberculosis resistant to the drugs, researchers said. Patients with more than 10 days of fluoroquinolone exposure before a TB diagnosis were seven times more likely to have... full story http://www.medpagetoday.com/InfectiousDisease/Tuberculosis/tb/15477

There's also something here that might explain why mainstream medicine might not be offering you the best care.

Read a review here

Wednesday, November 26, 2008

Inhaled Steroids Bring Greater Risk of Pneumonia

Steroid inhalers may raise pneumonia risks
Nov. 26, 2008

BALTIMORE, Nov. 26 (UPI) -- Steroid inhalers, commonly prescribed for people with pulmonary disease, can increase the risk of pneumonia, U.S. researchers said.

The Johns Hopkins University study also found that while inhalers helped, they did not extend a patient's life after a year of use, The Baltimore Sun reported Wednesday.

While medical experts have known for years that inhalers are effective in treating wheezing and breathlessness brought on by chronic obstructive pulmonary disease, doctors raised questions about steroid inhalers' side effects and whether they extended a patient's life, said the study's lead author, M. Bradley Drummond, a pulmonologist at the Johns Hopkins School of Medicine.

In the study, investigators examined 11 clinical trials, including 14,426 patients, comparing the incidence of pneumonia in those who used inhalers against those who did not.

Researchers said they weren't sure why inhalers increased the risk of pneumonia, but one theory is that they may weaken a person's immune system.

"Because these agents are so effective at controlling symptoms, we do feel there is a good role for inhaled steroids for treating COPD," Drummond said. "But for some patients there may be more harm than benefits."

Drummond said patients who use inhalers should not stop doing so, but talk with their physicians if they have concerns.

Common trade names for this class of drug in the US include Beclovent, Flovent, and Pulmicort, Aerobid and Azmacort.

For one example, using Flovent, also known generically as fluticasone, this is a fluoride based product. There would be an additive factor in that inhaler propellants have traditionally been fluoride based solutions (two chlorofluorocarbon propellants: trichlorofluoromethane and dichlorodifluoromethane).

People using these products should be closely monitored for respiratory function but adrenal insufficiency as well as immune and thyroid function and bone density.

It is not enough that the steroid use can impair immune and endocrine function but bone health as well, especially when the products have a higher than average percentage of fluoride compounds.

More likely than not the higher risk of pneumonia could be correlated with steroid induced immune suppression. Data show upper respiratory infection as a major side effect.

Calcium and DHEA may be depleted using these products also.

Inhaled steroids in the mouth promote Candida albicans(yeast)infections there and also disperse steroids throughout the body(absorbed via the mucous membrane).

 
Design by Free WordPress Themes | Bloggerized by Lasantha - Premium Blogger Themes | Macys Printable Coupons