Black Cumin and Pancreatic Cancer

UPDATE: Feb 2011 - Gernod Katzer's Spice pages are a resource I frequently use  to help people learn more about the benefits of herbs for health.  Here is the page on Nigella sativa

Original post date April 2009

For Black oil purchases please contact us.

See also enzymes for pancreatic cancer and other related articles here on Natural Health News (search window)

DENVER, April 21 (UPI) -- An anti-inflammatory herbal extract may inhibit pancreatic cancer, U.S. researchers say.

Thymoquinone -- the major constituent of the oil extract from a Middle Eastern herbal seed called Nigella sativa used as a traditional medicinal in Middle Eastern and Asian countries -- reduces the release of inflammatory mediators in pancreatic cancer cells.

Dr. Hwyda Arafat of the Jefferson Medical College of Thomas Jefferson University in Philadelphia, who was the study leader, says thymoquinone almost completely abolished the expression of several inflammatory cytokines, including: TNF-alpha, interleukin-1beta, interleukin-8, Cox-2 and MCP-1.

This effect was superior to the effect of trichostatin A -- an inflammation inhibitor already shown to ameliorate inflammation-associated cancers.

The herb also inhibited the activation and synthesis of NF-kappaB, a transcription factor that has been implicated in inflammation-associated cancer. Activation of NF-kappaB has been observed in pancreatic cancer and may be a factor in pancreatic cancer's resistance to chemotherapeutic agents.

"These are very exciting and novel results," Arafat said in a statement. "These potent effects show promise for the herb as a potential preventive and therapeutic strategy for pancreatic cancer. More importantly, the herb and oil are safe when used moderately, and have been used for thousands of years without reported toxic effects."

The findings are being presented at the American Association for Cancer Research's 100th annual meeting in Denver.

Clinical Data on Black Seed Herb

Black seed is used for treating gastrointestinal conditions including gas, colic, diarrhea, dysentery, constipation and haemorrhoids. It is also used for respiratory conditions, including asthma, allergies, cough, bronchitis, emphysema, flu and congestion. Additionally, it is used as an antihypertensive, immunoprotectant, anticancer agent, and vermifuge. It is used orally for women's health: including as a contraceptive, for stimulation of menstruation, and increasing milk flow.

In allergic conditions, black seed may have antihistamine effects. Black seed is thought to have immunoprotectant effects. Preliminary evidence suggests it may help minimize chemotherapy-induced decreases in hemoglobin and leukocyte counts. Black seed may be beneficial as an anticancer agent. According to preliminary studies, black seed may inhibit stomach tumors, carcinoma, and Ehrlich ascites carcinoma.

Black seed is reported to have been used for over 2000 years. Recordings mention it as far back as 1400 years. Black seed was found in the tomb of King Tutankhamen.

Published Clinical Studies
Black Seed Herb

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production.(click here to view report)

Neuropharmacological activity of Nigella sativa L. extracts.(Click here to view)

Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.(Click here to view)

Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress.(Click here to view)

Delayed apoptosis upon the treatment of Hep-2 cells with black seed.(Click here to view)

Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells.(Click here to view)

Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage.(Click here to view)

Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases.(Click here to view)

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide production.

Mahmood MS, Gilani AH, Khwaja A, Rashid A, Ashfaq MK.

Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi, Pakistan.

The in vitro effect of aqueous extract of Nigella sativa seeds on nitric oxide (NO) production by murine macrophages was studied. Murine peritoneal macrophages were pre-incubated with the extract and then activated with Escherichia coli lipopolysaccharride. NO production was measured after 24 hours by spectrophotometry. The plant extract caused a dose-dependent decrease in NO production. Dialyzed preparation of the extract did not affect NO production. However, the boiled fraction of the extract resulted in a dose-dependent inhibition of NO apparently comparable to that of the whole extract. These results indicate that the aqueous extract of N. sativa seeds exhibits an inhibitory effect on nitric oxide production by murine macrophages and the active component(s) is/are non-protein in nature. In view of the fact that nitric oxide is a pro-inflammatory mediator, this study validates the traditional use of the Nigella sativa seeds for the treatment of rheumatism. Copyright 2003 John Wiley & Sons, Ltd.

PMID: 13680825 [PubMed - indexed for MEDLINE]

Neuropharmacological activity of Nigella sativa L. extracts.

Al-Naggar TB, Gomez-Serranillos MP, Carretero ME, Villar AM.

Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.

Pharmacological studies have been conducted on the aqueous and methanol extracts of defatted Nigella sativa L. seeds to evaluate their effects on the central nervous system (CNS) and on analgesic activity. The observations suggest that the two extracts of Nigella sativa possesses a potent CNS and analgesic activity (depressant action especially in the case of the methanolic extract).

PMID: 12902052 [PubMed - indexed for MEDLINE]

Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis.

Salim EI, Fukushima S.

Laboratory of Experimental and Molecular Carcinogenesis, Department of Zoology, Faculty of Science, Tanta University, Tanta 31527-Egypt.

Chemopreventive effects of orally administered Nigella sativa oil on the induction and development of 1,2-dimethylhydrazine-induced aberrant crypt foci (ACF), putative preneoplastic lesions for colon cancer, were investigated in Fischer 344 rats. Starting at 6 wk of age, 45 male rats (groups 1-3) were subcutaneously injected with DMH once a week for 3 wk. Group 1 (15 rats) served as a carcinogen control group without N. sativa administration. Group 2 or 3 (15 rats each) were given the oil in the postinitiation stage or in the initiation stage, respectively. Animals of group 4 (11 rats) were injected with 0.9% saline and received N. sativa oil from the beginning until the termination. At sacrifice, 14 wk after the start, the total numbers of ACF as well as those with at least four crypts were significantly reduced in group 2 (P < 0.01). However, treatment with N. sativa oil in the initiation stage (group 3) did not exhibit significant inhibitory effects except on foci with only one aberrant crypt. Immunohistochemical analysis of 5-bromo-2'.-deoxyuridine labeling in colonic crypts revealed the N. sativa oil to have significant antiproliferative activity in both initiation and postinitiation stages and especially in the latter. Histological examination revealed no pathological changes in the liver, kidneys, spleen, or other organs of rats treated with N. sativa. In addition, biochemical parameters of blood and urine as well as body weight gain were not affected. These findings demonstrate that the volatile oil of N. sativa has the ability to inhibit colon carcinogenesis of rats in the postinitiation stage, with no evident adverse side effects, and that the inhibition may be associated, in part, with suppression of cell proliferation in the colonic mucosa. PMID: 12881014 [PubMed - in process] Nigella sativa (black cumin) ameliorates potassium bromate-induced early events of carcinogenesis: diminution of oxidative stress. Khan N, Sharma S, Sultana S. Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Faculty of Science, Jamia Hamdard, Hamdard University, New Delhi 110 062, India. Potassium bromate (KBrO3) is a potent nephrotoxic agent. In this paper, we report the chemopreventive effect of Nigella sativa (black cumin) on KBrO3-mediated renal oxidative stress, toxicity and tumor promotion response in rats. KBrO3 (125 mg/kg body weight, intraperitoneally) enhances lipid peroxidation, gamma-glutamyl transpeptidase, hydrogen peroxide and xanthine oxidase with reduction in the activities of renal antioxidant enzymes and renal glutathione content. A marked increase in blood urea nitrogen and serum creatinine has also been observed. KBrO3 treatment also enhances ornithine decarboxylase (ODC) activity and [3H] thymidine incorporation into renal DNA. Prophylaxis of rats orally with Nigella sativa extract (50 mg/kg body weight and 100 mg/kg body weight) resulted in a significant decrease in renal microsomal lipid peroxidation (P < 0.001), gamma-glutamyl transpeptidase (P < 0.001), H2O2 (P < 0.001) and xanthine oxidase (P < 0.05). There was significant recovery of renal glutathione content (P < 0.01) and antioxidant enzymes (P < 0.001). There was also reversal in the enhancement of blood urea nitrogen, serum creatinine, renal ODC activity and DNA synthesis (P < 0.001). Data suggest that Nigella sativa is a potent chemopreventive agent and may suppress KBrO3-mediated renal oxidative stress, toxicity and tumour promotion response in rats. PMID: 12755470 [PubMed - indexed for MEDLINE]
More Info - Clinical Studies - References - Buy Black Seed Oil now
Delayed apoptosis upon the treatment of Hep-2 cells with black seed. Corder C, Benghuzzi H, Tucci M, Cason Z. University of Mississippi Medical Center, Jackson, MS 39216, USA. Nigella sativa (Black seed, BS) has been used to promote health and fight disease for centuries. The objectives of this investigation were: (1) to study whether agents such as cortisol and LPS alone or in combination induce cellular (Hep-2, laryngeal carcinoma) damage with time in culture (24, 48, and 72 hours) using apoptosis as a marker, (2) to determine if an immune stimulant such as BS, can protect Hep-2 cells from insult and ultimately thwart the programmed cells death mechanism. A total of 54 Hep-2 cell/tubes (50,000 cells per tube) were divided into six equal groups. Group one served as untreated control, while groups 2-6 were treated with either cortisol (10 ng/ml), LPS (10 micrograms/ml), BS (25 micrograms/ml), or a combination of LPS and cortisol and cortisol plus LPS plus BS, respectively. At the end of each phase the cells were harvested, heat fixed and stained with H&E to evaluate morphological changes. Immunohistochemistry, using antibodies against caspace-3 to evaluate cells undergoing apoptosis was conducted in all groups. The results of this study showed evidence of cells undergoing apoptosis at different magnitudes in all groups. However, the most dramatic change was seen in groups containing cortisol and LPS alone or in combination. This was supported by the fact that there were several adaptive responses observed in all phases. In addition, the exposure of BS to cells pretreated with cortisol and LPS showed evidence of protection against the progressive apoptosis. PMID: 12724921 [PubMed - indexed for MEDLINE] Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Farah IO, Begum RA. Jackson State University, Jackson, MS 39217, USA. N. Sativa L., an oriental spice, has long been used as a natural medicine for treatment of many acute as well as chronic conditions. It has been used in the treatment of diabetes, hypertension, and dermatological conditions. There has been very few studies on the effects of N. Sativa as cancer prevention/therapy. Our objective therefore, was to expose MCF-7 breast cancer cells to aqueous and alcohol extracts and in combination with H2O2 as an oxidative stressor. Measurement of cell survival under various concentrations and combinations was conducted using standard cell culture techniques, exposure protocols in 96 well plates and Fluoro-spectrosphotometry. Following cellular growth to 90% confluency, exposure to water (WE) and ethanol (AE) extracts of N. sativa and H2O2 was performed. Toxicity index (LC50) was calculated from percent survival using regression analysis. Results showed that the alcohol extract and its combinations were able to completely inactivate the MCF-7 cells (LC50 ranged from 377.16-573.79 in descending potency for H2O2 + AE, AE and Mix of WE and AE). H2O2 alone effectively inactivated MCF-7 cells (LC50 = 460.94). The least effective combinations in descending potency were WE + H2O2, WE + AE + H2O2, and WE (LC50 were 725.79, 765.94, and 940.5 respectively. Combinations other than AE + H2O2 showed possible interactions, which lead to reduction in their potency. In conclusion, N. Sativa alone or in combination with oxidative stress were found to be effective in vitro in inactivating MCF-7 breast cancer cells, unveiling opportunities for promising results in the field of prevention and treatment of cancer. PMID: 12724920 [PubMed - indexed for MEDLINE] Protective effect of Nigella sativa seeds against carbon tetrachloride-induced liver damage. Al-Ghamdi MS. Department of Pharmacology, College of Medicine, King Faisal University, Dammam, Saudi Arabia. mghamdi@Dammam.kfu.edu.sa It has been reported that Nigella sativa oil possesses hepatoprotective effects in some models of liver toxicity. However, it is N. sativa seeds that are used in the treatment of liver ailments in folk medicine rather than its oil. Therefore, the aim of this study was to investigate the effect of the aqueous suspension of N. sativa on carbon tetrachloride (CCL4)-induced liver damage. Aqueous suspension of the seeds was given orally at two dose levels (250 mg/kg and 500 mg/kg) for five days. CCL4 (250 microl/kg intraperitoneally / day in olive oil) was given to the experimental group on days 4 and 5, while the control group was only treated with the vehicles. Animals treated with CCL4 showed remarkable centrilobular fatty changes and moderate inflammatory infiltrate in the form of neutrophil and mononuclear cells when compared to the controls. This effect was significantly decreased in animals pretreated with N. sativa. Histopathological or biochemical changes were not evident following administration of N. sativa alone. Serum levels of aspartic transaminase (AST), and L-alanine aminotransferase (ALT) were slightly decreased while lactate dehydrogenase (LDH) was significantly increased in animals treated with CCL4 when compared to the control group. LDH was restored to normal but ALT and AST levels were increased in animals pretreated with N. sativa. In conclusion, N. sativa seeds appeared to be safe and possibly protective against CCL4-induced hepatotoxicity. However, further studies may still be needed prior to supporting its use in folk medicine for hepatic diseases. PMID: 14696675 [PubMed - in process] Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H. Humboldt University, Berlin, School of Medicine, Institute for Transfusion Medicine, Charite University Hospital, Berlin, Germany. Nigella sativa (black seed) is an important medicinal herb. In many Arabian, Asian and African countries, black seed oil is used as a natural remedy for a wide range of diseases, including various allergies. The plant's mechanism of action is still largely unknown. Due to the lack of study data on its efficacy in allergies, four studies on the clinical efficacy of Nigella sativa in allergic diseases are presented. In these studies, a total of 152 patients with allergic diseases (allergic rhinitis, bronchial asthma, atopic eczema) were treated with Nigella sativa oil, given in capsules at a dose of 40 to 80 mg/kg/day. The patients scored the subjective severity of target symptoms using a predefined scale. The following laboratory parameters were investigated: IgE, eosinophil count, endogenous cortisol in plasma and urine, ACTH, triglycerides, total cholesterol, LDL and HDL cholesterol and lymphocyte subpopulations. The score of subjective feeling decreased over the course of treatment with black seed oil in all four studies. A slight decrease in plasma triglycerides and a discrete increase in HDL cholesterol occurred while the lymphocyte subpopulations, endogenous cortisol levels and ACTH release remained unchanged. Black seed oil therefore proved to be an effective adjuvant for the treatment of allergic diseases. Copyright 2003 John Wiley & Sons, Ltd. PMID: 14669258 [PubMed - in process]

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References Hanafy MS, Hatem ME. Studies on the antimicrobial activity of Black seed seed (black cumin). J Ethnopharmacol 1991;34(2-3):275-8. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999. Akhtar MS, et al. Field trial of Saussurea lappa roots against nematodes and Nigella sativa seeds against cestodes in children. JPMA J Pak Med Assoc 1991 Aug;41(8)185-7. Tennekoon KH, Jeevathayaparan S, Kurukulasooriya AP, Karunanayake EH. Possible hepatotoxicity of Nigella sativa seeds and Dregea volubilis leaves. J Ethnopharmacol 1991;31(3):283-9. Keshri G, Singh MM, Lakshmi V, Kamboj VP. Post-coital contraceptive efficacy of the seeds of Black seed in rats. Indian J Physiol Pharmacol 1995;39(1):59-62. Aqel M, Shaheen R. Effects of the volatile oil of Black seed seeds on the uterine smooth muscle of rat and guinea pig. J Ethnopharmacol 1996;52(1):23-6. Nagi MN, Alam K, Badary OA, et al. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int 1999;47(1):153-9. Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Ann Allergy 1993;70(3):237-42. Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Black seed L. Anticancer Res 1998;18(3A):1527-32. Daba MH, Abdel-Rahman MS. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 1998;95(1):23-9. Salomi NJ, Nair SC, Jayawardhanan KK, et al. Antitumour principles from Black seed seeds. Cancer Lett 1992;63(1):41-6. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Black seed and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995;61(1):33-6. Haq A, Abdullatif M, Lobo PI, et al. Black seed: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity. Immunopharmacology 1995;30(2):147-55. Badary OA, Al-Shabanah OA, Nagi MN, et al. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev 1999;8(5):435-40. Medenica RD. Use of Black seed to increase immune function. U.S. Patent 5,482,711, issued January 9, 1996. Obtained from US Patent and Trademark Ofc on April 12, 2000. www.uspto.gov/patft/index.htm. Increases immune function. ~ U.S. Patents Sections, Antiviral Agents Bulletin #5,482,711 Black seed stimulates bone marrow and immune cells and raises the interferon production, protects normal cells against cell destroying effects of viruses, destroys tumor cells and raises the number of anti-bodies producing B cells. ~ Cancer Immuno-biology Laboratory ,South Carolina Black seed contains valuable unsaturated fatty acids, for example Linoleic and Gammalinolen acids get into the organism. By that it possible to reach a synthesis of important immune regulating substances derived as from Prostaglandin E1. Linoleic acid stabilizes the cell membranes and Prostaglandin has the effect of inhibiting inflammation. By that the immune reactions are stopped which cause the illnesses and which otherwise could be the start of many chronic illnesses like acne and hayfever right up to cancer. ~ Dr. Peter Schleicher Immunologist, Munich, Germany Black seed proves to have an ant histamine, ant-oxidant, anti-biotic, anti-mycotic and broncho-dilating effect. ~ Study of Black seed oil on humans, American Scientists Black seed is truly a remarkable herb that has been used for over 3000 years. It contains over 100 valuable components. It is a significant source of essential fatty acids, proteins, carbohydrates and other vitamins and minerals. " The seeds are also rich in sterols, especially beta-sitosterol, which is known to have anticarcinogenic activity". ~ Dr. Michael Tierra L.AC. O.M.D Black seed tests prove to be genuine universal remedy. ~ Pharmaceutical newspaper, Wissenschaftlicher Text Black seed is a valuable source of protein, carbohydrates, essential fatty acids, vitamins A, B1, B2, C and niacin as well as minerals such as calcium, potassium, iron, magnesium, selenium, magnesium and zinc. ~ Phytochemicals of Nigella sativa seeds. Food Chemistry

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Posted in: Black Cumin,Black seed,immune system health,natural health news,natural interferon,natural news,Nigella sativa,pancreatic cancer

Does Pancreatic Cancer Lurk for Years in Your Body?

Our organization, CHI ( Creating Health Institute ) offer the nutritional based method developed for pancreatic and liver cancer in the 1960s by Dr William Kelley.  This topic is of importance to me more now because a dear friend of many years is now faced with her husband's recent pancreatic cancer diagnosis.

Lethal pancreatic cancer 'grows for decades'

Pancreatic cancer may lurk in the body for many years before patients fall ill, US scientists say.Research hints at earlier opportunities to spot and treat the disease, which is fatal in 95% of cases.

Genetic analysis of tumours by the Howard Hughes Medical Institute and Johns Hopkins University suggested the first mutations may happen 20 years before they become lethal.
UK survival rates for the disease have not improved in the past 40 years.
The disease is often aggressive and unresponsive to treatment by the time it is diagnosed.
The study, published by the Nature journal, found that tumours appear to be slow growing.
InsightThey looked at tissue samples, both from the "primary" tumours in the pancreas, and from other parts of the body to which the cancer had spread, called "metastatic" tumours.
The DNA in every gene of these tumours was sequenced, looking for signs of mutations - points at which the genetic code has changed.
On average each metastatic tumour had 61 cancer-related mutations. Two-thirds of these had been present in the original pancreatic tumour.

It means that there is a window of opportunity for early detection of pancreatic cancer”

Dr Bert Vogelstein Howard Hughes Medical Institute

 

Because such genetic mutations occur at a relatively steady rate, this accumulation of mutations offers an insight into just how long the cancer had been developing and growing at each stage.

Using this "molecular clock", the researchers estimated that on average, it took 11.7 years for a single gene mutation in a pancreas cell to become a "mature" pancreatic tumour.
From this point, an average of another 6.8 years elapsed before cells from the pancreatic tumour formed a tumour in another organ.
However, once this stage had been reached, less than three years passed before the patient died.
So, from start to finish, the development of the disease took more than 20 years on average.
Researcher Dr Bert Vogelstein said that there had been two theories about why pancreatic tumours were so lethal - either that they were highly aggressive from the start, or that they were so advanced at the time of diagnosis, that little could be done.
He said: "We were surprised and pleased to discover that this second theory is correct, at least for a major fraction of tumours.
"It means that there is a window of opportunity for early detection of pancreatic cancer."
'Early diagnosis need'Dr Elizabeth Rapley, from the UK's Institute of Cancer Research, said that the findings also helped explain just why the disease was so hard to treat once it had spread around the body.
She said: "It showed that the genetic code changed as it spreads to other organs. This could mean that developing effective treatments for patients with advanced disease will be challenging."
The Pancreatic Cancer Research Fund welcomed the findings, but said that research was underfunded in the UK.
Chief executive Maggie Blanks said: "Survival rates have not improved in the past 40 years and whilst the disease is the UK's fifth biggest cause of cancer death, it receives less than 2% of overall research funding.
"I'm particularly pleased that the study underlines the need for early diagnosis as there is nothing currently available."

SOURCE

top 4 of 28 related Natural Health News posts

Natural Health News: Black Cumin and Pancreatic Cancer

Apr 22, 2009

The herb also inhibited the activation and synthesis of NF-kappaB, a transcription factor that has been implicated in inflammation-associated cancer. Activation of NF-kappaB has been observed in pancreatic cancer and may be a factor in ...

Fourteen Articles on Natural Health News Related to Pancreatic ...

Mar 30, 2010

NEW YORK (Reuters Health) - Higher methionine intake is apparently associated with a reduction in pancreatic cancer risk, according to a report in the January issue of Gastroenterology. Impaired methyl group metabolism may contribute to ...

Soft Drinks and Pancreatic Cancer

Feb 09, 2010

Monday Feb 8,2010 WASHINGTON (Reuters) – People who drink two or more sweetened soft drinks a week have a much higher risk of pancreatic cancer, an unusual but deadly cancer, researchers reported on Monday. ...

Natural Health News: Enjoy Your Holiday, GMO FREE

Jul 01, 2010

Of 190000 adults studied for seven years, those eating the most processed meat such as deli meats and hot dogs had a 68 percent greater risk of pancreatic cancer than those who ate the least. (4) Pancreatic cancer is especially ...

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Posted in: pancreatic cancer

Fourteen Articles on Natural Health News Related to Pancreatic Cancer and...

Here is number 15, dating back to 2007, that may not have been brought to your attention. Methionine is a sulfur bearing molecule necessary to health and healing.

Methionine may ward off pancreatic cancer

NEW YORK (Reuters Health) - Higher methionine intake is apparently associated with a reduction in pancreatic cancer risk, according to a report in the January issue of Gastroenterology.

Impaired methyl group metabolism may contribute to pancreatic diseases and carcinogenesis, the authors explain, suggesting that methyl group donors like methionine could influence the risk of pancreatic cancer.

Dr. Susanna C. Larsson from the Karolinska Institute, Stockholm, Sweden, and associates examined intakes of methionine and vitamin B6 in relation to the incidence of pancreatic cancer in the Swedish Mammography Cohort and Cohort of Swedish Men. The study comprised nearly 82,000 men and women aged 45 to 83 years.

During a mean follow-up of 7.2 years, 147 incident cases of pancreatic cancer were diagnosed.

The multivariate rate ratio for pancreatic cancer was 0.44 for individuals in the highest quartile of methionine intake compared with those in the lowest quartile, the researchers found.

The inverse association between methionine intake and pancreatic cancer was more pronounced in smokers than nonsmokers, the investigators note. There was no interaction between alcohol consumption and methionine intake and pancreatic cancer risk.

There was no significant association between vitamin B6 intake and pancreatic cancer risk, the report indicates.

"The results from this prospective study suggest that higher intake of methionine may reduce the risk of pancreatic cancer," Larsson and colleagues conclude. "Foods rich in methionine include fish, poultry, meat, legumes, and dairy products," they add.

"The results could be important because pancreatic cancer, now the 4th most common cause of cancer mortality in the United States, has an extremely high mortality rate," write Dr. Albert B. Lowenfels and Dr. Patrick Maisonneuve from New York Medical College, Valhalla, New York in a related editorial.

"Even though the authors adjusted for many pancreatic cancer risk factors," the editorial goes on, "there is still the possibility that the apparent protective function of methionine is related to confounding by another dietary or nondietary protective factor."

Lowenfels and Maisonneuve conclude: "Before suggesting that our patients increase their intake of methionine, we need substantial additional data concerning efficacy and safety issues."

Gastroenterology 2007;132:113-118,441-443.

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Posted in: methionine,pancreatic cancer

Soft Drinks and Pancreatic Cancer

Most soda today is made with HFCS (high fructose corn syrup) and it seems as if this, along with the very toxic artificial sweeteners used in soda, causes many health problems often not discussed in the media.  It comes as no surprise that soda consumption can lead to this serious disease.  However, don't overlook the use of green tea and risk of pancreatic cancer.

Most HFCS is made from GMO corn and this genetic modification may also be a contributing factor.

The better news is that there are things you can do for pancreatic health, and also for pancreatic cancer naturally.

See also: www.leaflady.org/sweet_but_not_so_innocent.htm
www.leaflady.org/fructose.htm
http://naturalhealthnews.blogspot.com/2008/12/dangers-of-hfcs.html

Monday Feb 8,2010 WASHINGTON (Reuters) – People who drink two or more sweetened soft drinks a week have a much higher risk of pancreatic cancer, an unusual but deadly cancer, researchers reported on Monday.
People who drank mostly fruit juice instead of sodas did not have the same risk, the study of 60,000 people in Singapore found.
Sugar may be to blame but people who drink sweetened sodas regularly often have other poor health habits, said Mark Pereira of the University of Minnesota, who led the study.
"The high levels of sugar in soft drinks may be increasing the level of insulin in the body, which we think contributes to pancreatic cancer cell growth," Pereira said in a statement.
Insulin, which helps the body metabolize sugar, is made in the pancreas.
Writing in the journal Cancer Epidemiology, Biomarkers & Prevention, Pereira and colleagues said they followed 60,524 men and women in the Singapore Chinese Health Study for 14 years.
Over that time, 140 of the volunteers developed pancreatic cancer. Those who drank two or more soft drinks a week had an 87 percent higher risk of being among those who got pancreatic cancer.
Pereira said he believed the findings would apply elsewhere.
"Singapore is a wealthy country with excellent healthcare. Favorite pastimes are eating and shopping, so the findings should apply to other western countries," he said.
But Susan Mayne of the Yale Cancer Center at Yale University in Connecticut was cautious.
"Although this study found a risk, the finding was based on a relatively small number of cases and it remains unclear whether it is a causal association or not," said Mayne, who serves on the board of the journal, which is published by the American Association for Cancer Research.
"Soft drink consumption in Singapore was associated with several other adverse health behaviors such as smoking and red meat intake, which we can't accurately control for."
Other studies have linked pancreatic cancer to red meat, especially burned or charred meat.
Pancreatic cancer is one of the deadliest forms of cancer, with 230,000 cases globally. In the United States, 37,680 people are diagnosed with pancreatic cancer in a year and 34,290 die of it.
The American Cancer Society says the five-year survival rate for pancreatic cancer patients is about 5 percent.
Some researchers believe high sugar intake may fuel some forms of cancer, although the evidence has been contradictory. Tumor cells use more glucose than other cells.
One 12-ounce (355 ml) can of non-diet soda contains about 130 calories, almost all of them from sugar.
(Editing by John O'Callaghan)
http://news.yahoo.com/s/nm/20100208/hl_nm/us_cancer_pancreas_sodas/print

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Posted in: aspartame,diet soda,pancreatic cancer,soda,soft drinks,splenda,sucralose,sugar

Patrick Swayze and Cancer Thoughts

I am not much of a TV watcher and for the most part I have one so I can watch movies or play the workout videos I use as part of my daily fitness plan.

Last evening I made a deviation from the norm by watching the Patrick Swayze interview with Barbara Walters.

I was really most interested in what Patrick had to say, and his wife of almost four decades.

I also wanted to hear about the treatment he chose.

I admit I'm a Swayze fan of many years. I too enjoyed some youthful romantic escapades in the Catskills, and I hope his "ghost" hangs around from time to time.

He's been most courageous in his ability to be open and public through his illness and hopefully this stand will help many others. One thing he said that resonated with my work was what he said about how the chemo tore up his insides.

This is important on several levels. First of all this is such a common issue in chemotherapy and its one that is too frequently not addressed.

I have a friend who was just recently diagnosed with AML, a form of leukemia. I sent his wife a abstract I put together on nutrient deletions of chemotherapy drugs. This is a critical issue because of the wasting that so often is related to lack of nutrition and toxic body states caused by the chemo.

I also sent his wife another article written by Dr. H. Kenneth Schueler from New York. Dr. Schueler recently had one of his articles, "Clinical Trial of Pancreatic Enzymes: One View" included in Ralph Moss's newsletter.

This treatment used by Dr. Gonzalez, is based on the work of a dentist, Dr. William D. Kelley. Dr. Kelley was diagnosed in 1962 with pancreatic and liver cancer. He passed away in 2005.

Dr. Kelley's method is soundly based in nutrition. It is also brilliant in its understanding of physiology and biochemistry in the human body. It is one in which I have been educated, and I've seen the good results.

Gonzalez addresses the issue of toxic overload resulting from chemo and how current treatment models do not allow the body to process this waste. He also addresses nutrition and just how important this is in any cancer treatment plan. His research has shown about an 83% cure rate.

As Dr. Schueler says, we need to look again at this program, especially for pancreatic cancer. I couldn't agree more!

Nutrient Depletion in Chemotherapy- general to all chemo drugs in relation to side effects: dysbiosis, stomatitis, pancreatitis, adynamic ileus, gastric mucosa damage and realted damage to microvilli in small intestine, nausea, vomiting, diarrhea and constipation.

All of the above side effects relate to malabsorption issues and to a high state of inflammation. The end result is malnutrition. Natural approaches can help substantially with all of the above. (GE)

Consider too the impact of over use of acid reflux drugs and the rising incidence of gluten allergy. There's more to it than smoking.

And you do not have to lose your hair! There is a natural supplement that not only can fight cancers but it protects you from losing hair.

More articles -

http://naturalhealthnews.blogspot.com/2009/03/cancer-nutritional-and-environmental.html

http://naturalhealthnews.blogspot.com/2008/09/finding-gene-is-only-one-part-of.html

http://naturalhealthnews.blogspot.com/2009/03/supplements-reduce-adverse-effects-of.html

http://naturalhealthnews.blogspot.com/2009/04/black-cumin-and-pancreatic-cancer.html

Many more articles may be found by putting "cancer" in the search box in the header.

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Posted in: Cancer,Dr. Nicholas Gonzalez,Ken Schueler,natural cancer care,natural health news,pancreatic cancer,Patrick Swayze,Ralph Moss

Today's Drug Promoting Insanity

As I've been saying lately, what we have in the US is medical care, not health care. And the medical care we have ranks very low in comparison to many other countries.

There are many reasons for this poor state of affairs, and here are a few reasons why things are as they are -

1. Older people should take anti hypertensive drugs even if they do not have hypertension.

This idea seems to be the brainchild of some medical researchers in the UK. They believe a "polypill" made up of the standard drugs used currently as the cookie cutter treatment for blood pressure will prevent heart disease and stroke.

My choice would be vitamin E and magnesium, plus a more customized individual plan for anyone concerned about these issues.

2. The anti-cholesterol drug fenofibrate (Tricor or Triglide)appears to reduce risks of amputation for diabetics by as much as 36 percent, a study has found. This drug runs about $75 for 90 pills. And it has some great side effects I know everyone wants to experience, especially when hit with their impact by surprise because the prescriber overlooked explaining them, as required by law.

The study was published in a special edition on diabetes by The Lancet, which included another study on how rigorous monitoring and control of blood sugar reduces heart attacks.

Well, just for starters, how is amputation directly related to controlling blood sugar and reducing heart attacks?

Perhaps these medical whiz kids need to go back to the drawing board to read the research that says anti-cholesterol drugs do not reduce risk of heart attack, and they don't really do much for LDL or blood sugar lowering either.

However, if a person with diabetes takes adequate amounts of vitamin E daily, they will find that they can prevent neuropathy and the reduce the risk of losing toes, feet, or limbs.

And because vitamin E is an oxygenator it can act to lower blood pressure as doing is increased over time.

A little Alli-C thrown in the mix easily increases the benefits, and garlic has some blood sugar lowering effect as well.

Then there is Kufner's Powder, heavily laden with B vitamins and trace minerals, shown in the very first hospital based study to reverse gangrene in a limb of an older man with diabetes. And consider enzymes, especially lipase, it might be beneficial.

Seems to be another indication we need more open minds and more creative thinking in medicine now days...

3. "A study by Cancer Research UK found that pancreatic cancer can spread quickly to a tumor, despite a healthy blood supply, and gave evidence why conventional cancer treatments such as Eli Lilly and Co's Gemzar were often ineffective.

The study found that combining cancer treatment Gemzar with Infinity Pharmaceutical's experimental drug IPI-926 made the treatment work better in mice with pancreatic cancer."

Yes, the treatment works better in mice!

And the statistics are not good: "Pancreatic cancer is diagnosed in 230,000 people across the world each year, with 7,600 new cases in Britain and 37,000 new cases in the United States, according to Cancer Research UK."

So what might you do?

Well, there is a natural treatment that has been proven in an FDA funded study that seems to get up to an 83% cure rate.

It has lots of vitamins and enzymes, plus a different nutritional approach.

And after you've looked over just these three items consider that in 1999, the Institute of Medicine (IOM) issued an alarming report titled "To Err is Human," detailing the toll of preventable medical errors in the U.S; it estimated that up to 98,000 Americans die annually from them.

Comments on this study show that now a decade later as more than 100,000 people are dying from the same cause, as the CDC reports, why aren't the "right" questions being asked.

Are we really hoping for reform in medical care?

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Posted in: amputation,diabetes,disease prevention,health care reform,high blood pressure,medical errors,natural healing,natural health news,pancreatic cancer,Vitamins improve health

Green Tea Downside Possible

I am aware that there are many studies supporting the use of ECGC from green tea for cancer and other health concerns.

I am also aware of the many serious side effects of cancer drugs which commonly this information is not provided those patients receiving them. This distresses me more when dealing with recombinant pharmaceuticals known as genetically engineered drugs.

What most people who strongly stand behind the use of green tea do not know is that it has the potential to cause pancreatic cancer.

I am sure the FDA has not tested all the possible interactions between drugs and I am also fairly certain that the same goes for herbal products.

Probably a good study would be to show how herbs and other nutritional approaches to cancer do more good than harm. And how they often offer cure, without long term damaging side effects, when pharmaceuticals do not.

Green tea may block activity of common cancer drug

NEW YORK (Reuters Health) – Some components of green tea may counteract the beneficial effects of a widely used anti-cancer agent called Velcade, also known as bortezomib.

"We know that cancer patients look to green tea extracts among other natural supplements to complement their therapeutic regimens," Dr. Axel Schonthal, said in a statement. "We wanted to better understand how the compounds in green tea interact with a cytotoxic chemical therapy and how that may affect patient outcomes."

In lab studies, Schonthal, from the University of Southern California Keck School of Medicine, Los Angeles, and colleagues evaluated the impact of green tea compounds on the efficacy of bortezomib against multiple myeloma, a blood cancer, and glioblastoma, a malignant brain tumor.

Bortezomib normally fights cancer by inducing tumor cell death. However, Schonthal and colleagues were surprised to find that some of the green tea polyphenols and other components actually prevented bortezomib from killing tumor cells.

"Our surprising results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib," Schonthal said.

"The current evidence," Schonthal said, "is sufficient enough to strongly urge patients undergoing bortezomib therapy to abstain from consuming green tea products, particularly the widely available, highly concentrated green tea and EGCG (epigallocatechin gallate) products that are sold in liquid or capsule form."

The findings of this study, the investigators emphasize, are specific for patients taking bortezomib as opposed to any other common cancer drug.

"Although the study has exposed detrimental effects of great tea in specific combination with Velcade, this should not minimize the previously reported potentially beneficial effect of this herb," Schonthal said. "Related studies with other types of cancer therapies are promising and green tea extract may actually improve the anticancer effects of other drugs."

SOURCE: Blood, online February 3, 2009.

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Posted in: American Cancer Society,bortezomib,consumer health,green tea,independent information,natural health news,natural news,pancreatic cancer

Justice Ginsburg, Randy Pausch, and others

A news report this morning relaying the dismal statistics about pancreatic cancer survival identified that it is the 4th cause of death of all cancer today.

The report included all the issues of mainstream treatment such as surgical removal of tumours, chemotherapy and radiation.

As the reporter added about the colon cancer Justice Ginsburg recovered from not so long ago, one has to wonder what effect that chemo and/or radiation had on her recent situation.

What this reporter failed to include in her story is a cancer treatment developed for pancreatic and liver cancer about 50 years ago. This more natural approach seems to offer an 83 per cent cure rate according to the most recent study.

This is a far sight greater than the 10 percent chance of cure offered by current allopathic methods.

And, by the way, is any one asking what might be the cause this rash of pancreatic cancer cases? Is it the food, is it cancer treatment, is is wheat allergy or just what is the stimulating factor? Or perhaps I should ask just where is a good epidemiologist with an inquiring mind.

Here are a few related articles from Natural Health News -
http://naturalhealthnews.blogspot.com/2008/04/chemo-continues-to-damage.html
http://naturalhealthnews.blogspot.com/2008/05/grapes-for-good.html
http://naturalhealthnews.blogspot.com/2008/07/effective-cancer-therapy-dates-back-to.html
http://naturalhealthnews.blogspot.com/2008/08/benefits-of-vitamin-c-for-cancer.html
http://naturalhealthnews.blogspot.com/2008/09/finding-gene-is-only-one-part-of.html

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Posted in: health news,independent news,natural health news,natural news,pancreatic cancer,Randy Pausch,Ruth Bader Ginsburg