Showing posts with label nutrition. Show all posts
Showing posts with label nutrition. Show all posts

Thursday, April 14, 2011

A Tasty Way to Get More Magnesium

I personally like quinoa, mainly for its protein, but also its many uses.  I add organic quinoa flakes to oatmeal, pancakes, and other foods.  I like it in place of rice as it is gluten free.

I guess I'd like to have Larry's Markets' recipe for their quinoa salad with oranges.  In the interim I found one one I think I'll play with, my choice is to omit the corn.  But you may like it as it is in this recipe.

Quinoa salad: 
  • 1 cup quinoa, well rinsed
  • 1 cup frozen corn kernels, thawed
  • Juice of one lemon
  • 1 Tbs olive oil
  • 2 to 3 scallions, minced
  • Salt and black pepper, to taste
  • Bean salad:1 16-ounce (455g) can low sodium pinto beans, drained and rinsed
  • 1 cup diced tomato
  • 1 Tbs apple cider
  • 1/4 cup chopped parsley or cilantro
  • Freshly ground black pepper, to taste
  • Garnishes: Pumpkin seeds
  • Black olives
  • 1 red bell pepper, cut into strips

Directions

  • Boil 2 cups water (480mL) in a saucepan. Add the quinoa and simmer, covered, for 15 minutes. When done, fluff with a fork and transfer to a bowl. Combine quinoa with remaining ingredients for the quinoa salad.
  • While the quinoa cooks, toss the bean salad ingredients in another bowl.
  • To assemble, spread quinoa salad evenly on a platter. Leave a well in the center and mound bean salad into the well. Sprinkle with pumpkin seeds. Arrange olives and pepper strips around the edge. (Delicious Living)

Low magnesium linked to inflammation

The experiment revealed several findings: Fewer than half of the people in the study were getting enough dietary magnesium to meet the estimated average requirement (the amount estimated to meet the needs of 50% of people), and more than one-third had low magnesium levels in their blood.
People with low-magnesium diets had higher levels of C-reactive protein, a marker of inflammation that is closely correlated with cardiac risk.
A low magnesium diet was also associated with a higher body mass index, a number based on height and weight that is used to diagnose overweight and obesity. Scientists have found a close relationship between obesity and inflammation. CRP levels decreased in people in the magnesium group whose CRP levels were high at the beginning of the study, but increased in those in the placebo group.
“The findings show that many individuals have a low magnesium status associated with increased chronic inflammatory stress that could be alleviated by increased magnesium intake,” the study’s authors said. (Magnesium Research)
People with Diabetes (PWD) often have low magnesium levels: More on Magnesium



Quinoa is high in many health promoting nutrients, and you'll get about 90mg of magnesium from a half-cup serving.


Top Viewed articles (30+) re: Magnesium from Natural Health News
Dec 30, 2010
In 1995, researchers at the University Eye Clinic in Basel, Switzerland published a study on the effect of supplemental magnesium on glaucoma patients. A dose of 121.5 mg twice daily was administered to 10 glaucoma patients for one ...
Oct 24, 2007
(OMNS October 23, 2007) Over two-thirds of all Americans do not consume the recommended daily intake of magnesium. Even more alarming are data from a study showing that 19% of Americans do not consume even one-half of the government's ...
Nov 11, 2008
The relationship between high blood pressure and magnesium deficiency has been explored in several studies, producing conflicting evidence. A study published in the November 2002 issue of the Journal of Hypertension submits the ...
Apr 05, 2008
My therapy for restless leg (RLS as the pharma-media calls it) is based in magnesium but I add another nutrient or two, because for this situation the sum of the combination shows better benefit, and usually sooner, than magnesium alone ...

Tuesday, September 7, 2010

Dr Kelley

I am fortunate enough to have been educated in Dr Kelley's method, and well aware of the help it can offer to many. It is offered through Creating Health Institute.

ONE MAN ALONE: AN INVESTIGATION OF NUTRITION, CANCER, AND WILLIAM DONALD KELLEY

By Nicholas J. Gonzalez, MD
Dr. Gonzalez completed this comprehensive analysis of Dr. Kelley’s approach in 1986 as partial fulfillment of his immunology fellowship under the direction of Robert A. Good, PhD, MD, founder of “Modern Immunology.”

Although never previously published, this monograph has been generating interest in the alternative and conventional medical world for over two decades. This book documents Dr. Gonzalez’s five year evaluation of hundreds of Dr. Kelley’s patients and illustrates the value of Dr. Kelley’s nutritional-enzyme program.

Includes 50 representative case histories of patients diagnosed with a variety of poor prognosis or terminal cancer who did well under Dr. Kelley’s care.

Learn about the natural cancer treatment and Dr. Kelley’s success.

Friday, August 27, 2010

Big Food, Big AG, Fake Food Pyramids and Your Health

Marion Nestle - We need new food policy

FOOD, Inc. see it here
Insight into were our food comes from and how it is produced ....and the big companies that control everything.


http://geraldcelentechannel.blogspot.com/2010/08/food-inc-corporate-controlled-food.html


Food is Medicine, GM Food is Poison
Among all developed countries, Americans are the fattest people in the world. The World Health Organization found over 60% of the American population is obese or overweight. Even more disturbing, the U.S. is the only country in the developed world to label obesity a national security health risk. Top Pentagon officials have warned Americans are becoming so fat, most of those volunteering for the Army are disqualified because of their size. Child obesity is also on the rise in the U.S. The Centers for Disease Control estimates 1 in every 3 American kids are either obese or overweight. Jeffrey Smith, the author of Seeds of Deception, points to the mass production and consumption of genetically modified foods in the U.S. as a possible source of the problem.


http://geraldcelentechannel.blogspot.com/2010/08/food-is-medicine-gm-food-is-poison.html

Friday, July 23, 2010

Eating LESS Meat is the way to lose weight ? NOT!

When I saw this article circulating the airways and media venues, as well as the numerous tweets I received from the raw foodies and vegans I was laughing so hard my sides hurt.

Hard to say who paid for this room of alleged researchers to come up with the findings, but you really do have to question this.

When choosing your food plan there is quite a lot more that goes into selecting what is correct for you.  Relying on mass media isn't always the best place to start.

I use a specific test that helps you learn what type of metabolism you have, based on twelve types.  These types were developed 50 years ago based on solid nutrition research that preceded this method by another 30-40 years.  And at that time research had "meat". It was based on solid scientific guidelines and it wasn't usually tainted.

Another approach I use is an old and proven food program that will re-balance your biochemistry.

Then I look at your personal nutritional deficiencies, in an approach I developed over many years in this work and with many people of differing backgrounds.  I have a patent application pending.

Of course I defer to organic food, but I also provide information so you can select the healthiest food even when organic isn't available or you cannot afford it.

Some people can eat meat, some cannot.  The same follows for vegetarianism and veganism, raw or cooked fanciers.

I also into consideration the issues of feed lots and mass production of meat, hormones, and antibiotics, as well as the type of feeding used in this wing of the food industry. 

So you get a tailored plan, and you get educated.  You'll receive support and get some balanced exercise information too.

Because I charge for this service I know that not everyone will take advantage of it, or any of the parts of it. 

And ultimately because my work is based on education you might like to read the opinion of a trusted colleague on this latest babble.

TIP:  One serving of meat is about the size of a deck of cards, or as others may say, the size of the palm of your hand.

Sorry Dr Atkins

Monday, June 28, 2010

The Marvellous Health of Unvaccinated Children

Françoise Berthoud, MD [medical doctor, paediatrician]

June 25, 2010
Once upon a time, in April 2009 to be exact, I was invited to give a speech at a conference on vaccination.I was to talk after two of the best speakers France has to offer on the subject had their turn, journalist Sylvie Simon and biologist Michel Georget. At hearing them speak in the past, it was absolutely clear to me that the best option is to stay as far away from vaccines as possible. I just did not know what to do instead to best assure staying alive and well. As a paediatrician and homeopath qualified to speak on the subject, I decided to setup a conference called The Marvellous Health of Unvaccinated Children along with my friends, Sylvie and Michel. This work would later evolve into a book that analyses various life choices often made by families that do not vaccinate, including home birth, breastfeeding, simple therapies, good food (often vegetarian), a tranquil living environment and trust in the capacity of the body to heal itself.

In my life as a paediatrician, I had spent lots of time in dialogue with the parents who often needed to voice their fears about both disease and vaccines. We worked out together the best route for their children. Some chose not to vaccinate at all. Others held onto fear of disease, especially tetanus. In those cases, we postponed vaccination as much as possible and used a homeopathic protection and "cleansing" called nosode.

I worked in Switzerland where there is no real legal obligation to vaccinate, only great social pressure. In France, just a few kilometres from my office, there were four compulsory vaccinations at the time (BCG was fortunately removed in 2007, and three remain: Di Te Pol).

Some of the basis of my ability to speak on the marvellous health of unvaccinated children comes from my personal experience as a medical doctor, having collected years of feedback.
  • “My child began coughing immediately after the vaccination.”
  • “He has had constant ear aches since he was vaccinated.”
  • “My 16 years old daughter is completely unvaccinated. She is almost never sick. If she does get sick, it’s two days at the most.”
  • “The neighbour's kids followed normal vaccination guidelines. They are constantly sick and on antibiotics.”
That was not enough upon which to write a book; however. As it would turn out, I found these observations were paralleled over and over again all over the world. Follow me around the planet.

EUROPE

In England, Michel Odent, MD showed in two studies that children having received no Pertussis vaccine had 5-6 times less asthma than those who were vaccinated for it. The first study was on 450 babies from La Leche League; the second one on 125 children in a Steiner school. (1)

Throughout Europe, a group of mostly paediatricians studied 14,893 children in Steiner schools in Austria, Germany, Holland, Sweden and Switzerland and found that children living in "anthroposophist culture" (where vaccination is largely shunned) were in better health than the controls. (2)

In Germany, one of the European Steiner schools study researchers wrote, “In the eastern part of Berlin before the fall of the wall, we saw less allergies than in the west. This population was poorer, nearer nature and less vaccinated.” Too much hygiene is not always good. As UK researcher and originator of the “hygiene hypothesis” David Strachan might say, "give us this day our daily germs".


In Spain, Xavier Uriarte, MD and J. Manuel Marín, MD published a study in 1999 on 314 children they followed between 1975 to 2000. (3) This group of children is characterized by a majority of homebirth or natural births, prolonged breastfeeding, no vaccinations, holistic health education and no allopathic medicine. There were no serious diseases, few hospitalisations (mostly for traumas), and 3.3% asthma compared to the 20% in the general population. And of course, a lot of money was spared!

USA

The rate of autism in the U.S. is now an unthinkable 1 in 100. Those who are unvaccinated boast numbers that run in shocking contrast to the nation’s statistics. As this article is directed to the American people, I will not go on at length here. Most of you know the work of your very own journalist Dan Olmsted showing the incredible absence of autism in the unvaccinated Amish communities of Pennsylvania and Ohio.

Further impressive is Chicago-based Homefirst Medical Clinic run by a group of doctors including medical director Mayer Eisenstein, MD, JD, MPH. They have no known autism and super-scarce allergies in their children, many of whom were home deliveries, and most of whom have had no vaccinations. In 1985, I translated to French U.S. paediatrician Robert Mendelssohn, MD's How to Raise a Healthy Child in Spite of Your Doctor. Now I find concrete result in the marvellous health of kids whose doctors are his pupils! I like these synchronicities in my life.

AUSTRALIA

In 1942, Leslie Owen Bailey, founder of the Natural Health Society of Australia, accepted guardianship of 85 children whose mothers were unable to care for them. Among these 85 children, no vaccinations were ever given, no drugs were ever taken or used, and no operations were ever performed. The only malady that occurred was when 34 of the children developed chicken pox. They were immediately put to bed and given only pure water or fresh fruit juice. They all recovered quickly without after-effects. Investigations revealed that these children whilst at school had been swapping their healthy lunches for unhealthy conventional foods, so this outbreak was not altogether surprising.

Many of these children inherited poor health due to a history of illness and malnourishment in their mothers. Despite this, and the fact that they were never breastfed nor could enjoy the normal bonding of mother to child, they were able to grow into sturdy, self-reliant children.

NEW ZEALAND

Two studies done in New Zealand in 1992 and 1995 show that the unvaccinated children clearly have less allergies, less otitis (ear aches), less tonsillitis, less running noses, less epilepsies and less ADHD. (4)

JAPAN

An interesting period in Japan was 1975-1980, when a decision was made to begin the first vaccinations at two years of age instead of at two months. The reason was that more and more was discovered linking vaccines and cot-death (SIDS). A study was published in Pediatrics showing that from 1970 to January 1975, there were 57 cases of serious vaccine reactions, including 37 deaths. From February 1975 to August 1981 there were eight cases of serious vaccine reactions, including three deaths. Unfortunately for kids and their parents, the Japanese vaccination plan is now "normalized" again. The study shows well that the immune system is stronger at two years than at two months. How well would these kids have done had they not been vaccinated at all?

We find the same observation in a Journal of Allergy and Clinical Immunology study. Of 11,531 children studied at age seven, here are the results: vaccinated at two months, 13.8% are asthmatic, vaccinated between two and four months, 10.3%, vaccinated after four months, 5.9 %. Again, how well would these kids have done had they not been vaccinated at all?

THE LESSON LEARNED ON VACCINATION

As a concerned, compassionate and considerate paediatrician, I can only arrive at one conclusion.Unvaccinated children have by far the best chance of enjoying marvellous health. Any vaccination at all works to cripple the chances of this end.

2) Allergic diseases and atopic sensitization in children related to farming and anthroposophic lifestyle - Persifal study. Allergy 2006, 61 (4) : 414-421.

 

Monday, June 7, 2010

A New Look at Color and Food

Nutrition ambitions: "Nutritarian" diet is easy; just try to eat a rainbow
By Douglas Brown
The Denver Post, 06/07/2010

Vegetarians are defined by what they shun — meat. Vegans, who reject all food from animals, take it even further.

There are flexitarians, who eat a little bit of meat, and pescatarians, who skip meat but consume seafood. Raw foodists don't believe in cooking.

And now come the nutritarians.

Wednesday, April 28, 2010

Selecting Fruits and Vegetables for Your Best Health

From the BBC comes a good report on the ins and outs of the whys and wherefores of eating a varied diet, especially when it comes to fruits and vegetables. Get more information here and here.
'Pick the right veg' for health
Obvious choices of fruit and vegetables are not necessarily the healthiest, say researchers.

According to US experts, making simple swaps like eating sweet potatoes instead of carrots and papaya rather than oranges could make a difference.

Foods, like raspberries, watercress and kale, are richer in phytonutrients which may help prevent disease, they told a US meeting.

UK nutritionists said a balanced diet is essential to good health.

The British Nutrition Foundation warned that relying on eating a few select food types to boost health was ill-advised and said there was no such thing as a "superfood".
No one food can give you everything you need
Dr Emma Williams of the British Nutrition Foundation
Experts recommend five portions a day of fruit and veg in a healthy diet.

Plant foods are known to contain "phytonutrient" chemicals that can protect the heart and arteries and prevent cancers.

But the most popular varieties may not be the best, according to US researchers.

They analysed data from US health surveys of people's dietary habits to look at the most common sources of phytonutrients.

They found that for 10 of the 14 phytonutrients studied, a single food type accounted for two-thirds or more of an individual's consumption, regardless of how much fruit and veg they ate overall.

Carrots were the most common source of beta-carotene, oranges and orange juice the most common source of beta-cryptoxanthin, spinach the most common source of lutein/zeaxanthin, strawberries the most common source of ellagic acid and mustard the biggest provider of isothiocyanates.

However, for each of these phytonutrients there was a richer food source available.

Richer foods

Switching from carrots to sweet potatoes would nearly double beta-carotene intake, say the researchers.

Similarly papaya contains 15 times more beta-cryptoxanthin than oranges, while kale has three times more lutein/zeaxanthin than spinach.

Raspberries have three times more ellagic acid than strawberries and one cup of watercress contains as much isothiocyanate as four teaspoonfuls of mustard.

Study leader Keith Randolph, who is a technology strategist for the supplement company Nutrilite, said: "These data highlight the importance of not only the quantity but also the significant impact the quality and variety of the fruits and vegetables you eat can have on your health."

Dr Emma Williams of the British Nutrition Foundation said: "They are right that some foods are richer sources of phytonutrients.

"But at the end of the day, to be healthy you need to make sure you have a varied and balanced diet.

"No one food can give you everything you need."

The findings were presented at the 2010 Experimental Biology conference in Anaheim, California.

Story from BBC NEWS: http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/8645104.stm
Published: 2010/04/27 02:43:11 GMT © BBC MMX

Wednesday, March 31, 2010

Taking Too Many Pills

There is a recent TV commercial for Crestor that has a woman explaining about how her doctor put her on the drug to help her reduce LDL, or what is marketed as " bad cholesterol".

When I hear this commercial I want to have equal time to explain something very important to doctors and to women.   Since I don't have the gazillions of disposable income that the PhRMA companies have, I don't have a snowflake's chance in hell of this, so I'll address it here.

One of the most problematic health issues today is thyroid function.  Part of the problem is that it is not only overlooked as important in today's Big Insurance+Big PhRMA controlled medical care, but it is also porrly diagnosed.

Yes, folks, the TSH test won't tell you " squat" !

What also is missing is that thyroid dysfunction cause your cholesterol level to rise.

Since this concept is basic physiology why is your doctor pushing a drug on you to lower cholesterol when properly evaluating thyroid function is a much better place to start?

This is also very much related to gall bladder function which can be resolved without "cutting it out" !

Another generally overlooked is the vital part sound nutrition plays in the prevention and treatment of disease, yet mainstream media continues to ignore this vital concept.

Recently, the New York Times also looked at the issue of pushing pills, especially as the vultures from PhRMA and the buzzards from Big Insurance begin their efforts to round you up for the kill, following the passing of the so-called "health" bill. (Just recall that HillaryCare wanted everyone to be taking Prozac, and we know what a disaster the SSRI drugs have become.)
Risks Seen in Cholesterol Drug Use - "With the government’s blessing, a drug giant is about to expand the market for its blockbuster cholesterol medication Crestor to a new category of customers: as a preventive measure for millions of people who do not have cholesterol problems."
http://www.nytimes.com/2010/03/31/business/31statins.html?partner=rss&emc=rss

And so did the London Daily Mail
D. Mail 29.3.10 "A NATION OF PILL-POPPERS"
Dept of Health data reveals we each pick up more than 16 prescriptions a year on average, twice as many as 20 years ago. The boom is partly put down to a profit-hungry pharma industry inventing & exaggerating ailments & then blitzing doctors to boost sales. The NHS spent £22million a DAY on prescription drugs in England in 06 - a 60% rise in real terms on 10 years earlier.
-
(A colleague's comment: Prof. Michael Oliver, emeritus professor of Cardiology at Edinburgh University, wrote in the British Medical Journal in March last year that healthy older people are being turned into patients by GPs who are too quick to prescribe pills for high blood pressure, cholesterol & mild diabetes. The standard for these is based on much younger people's needs. The professor stated that few older people are allowed to enjoy being healthy as a bureaucractic demand for documentation can lead to over-diagnosis, over-treatment & unnecessary anxiety - known as "the medication of health." GPs are pressurised by the government to hit targets & this has overtaken personal advice from GPs. Incentives known as "Quality & Outcomes Framework" mean a proportion of GP practice-income is dependent on hitting targets. He questions whether patients are warned about medications' side-effects & whether older people could be allowed to return to their previous unencumbered & reasonably fit lives.
Please note that our organization offers an excellent thyroid testing kit, and health and nutrition counseling,
http://leaflady.org/detect.html

Saturday, March 20, 2010

Nutritional training for doctors too long overdue

LONDON, March 19 (UPI) -- Nutritional training is important to every area of clinical practice but has been long neglected, researchers in Britain said.

Dr. Penny Neild of St. George's Hospital in London and colleagues said the profession must take advantage of changes in medical education to ensure that all health professionals, but especially gut specialists, are given adequate training in nutrition.

The evidence shows healthcare professionals in general know little about how to assess and manage poor nutrition and gastroenterologists in particular need to be able to provide advice and expertise in general nutrition, artificial nutrition support, and intestinal failure, the researchers said.

"It is to be hoped that the requirement for more standardized and structured core nutrition training will be recognized and included in the revised curriculum for gastroenterology to be published in 2010," the researchers concluded.

The article is published in Frontline Gastroenterology, a new quarterly companion journal to Gut.
READ MORE

Wednesday, February 10, 2010

The Better Benefits of Nutrition

As the new DSM manual, used to establish insurance billing guidelines for the most part, is under development it seems likely that nutritional care for mental health and addiction disorder will most likely continue to be ignored. 

It is unfortunate that this researcher did not continue research utilizing nutritional therapy to see how improved nutrition supports mood and health.

Usually sweet cravings are indicative of deficiency in B vitamins and in many cases, protein as well.

At CHI we think it is better to treat nutritionally than rely on carcinogenic-benzene-fluoride containing antidepressants.
Sweet tooth 'hints at depression'
While most children like sweets, those with an extra-sweet tooth may be depressed or at higher risk of future alcohol problems, researchers say.
The US team report in the journal Addiction that certain children are especially drawn to very sweet tastes.
These were children who had a close relative with an alcohol problem or who themselves had symptoms of depression.
But it is unclear if the preference for the very sweet is down to genuine chemical differences or upbringing.
The researchers say sweet taste and alcohol trigger many of the same reward circuits in the brain.
It may be that even higher levels of sweetness are needed to make depressed children feel better
Lead researcher Julie Mennella
Lead author Julie Mennella said: "We know that sweet taste is rewarding to all kids and makes them feel good.
"In addition, certain groups of children may be especially attracted to the intense sweetness due to their underlying biology."
Experts say alcoholics tend to have a sweet tooth.
But the link is less clear in children. Other US researchers have shown that a preference for the sweetest drinks was found in the ones undergoing growth spurts.
In the latest study, the scientists at the Monell Chemical Senses Center asked 300 children aged five to 12, of whom half had a family member with alcohol dependency, to taste five sweet water drinks containing different amounts of sugar.
The children were asked to say which tasted the best and were also asked questions to check for depressive symptoms.
A quarter had symptoms that the researchers believed suggested they might be depressed.
Sweet tooth
Liking for intense sweetness was greatest in the 37 children who had both a family history of alcoholism and reported depressive symptoms.
The taste difference may be explained by differences like parental control over sweet consumption
Taste expert Professor Tim Jacob
These children preferred the drink containing the most sugar - 24% sucrose, which is equivalent to about 14 teaspoons of sugar in a cup of water and more than twice the level of sweetness in a typical cola.
This was a third more intense than the sweetness level preferred by the other children.
The researchers then decided to test whether the children's taste difference had any impact on their reaction to pain or discomfort - past studies have suggested sweets may help act as analgesics as well as mood lifters.
They found non-depressed children were able to tolerate keeping their hands in very cold water for longer if they had a sugar hit.
However, the extra sugar did nothing to the depressed children's pain threshold.
Cardiff University's Professor Tim Jacob, an expert in smell and taste, said the findings were interesting, but that it was hard to make firm conclusions or generalisations from one study alone.
He said the findings could be down to brain chemistry, but might also be explained by behaviour and upbringing.
"While it is true that sweet things activate reward circuits in the brain, the problem is that sweets and sugar are addictive, because the activation of these reward circuits causes opioid release, and with time more is needed to achieve the same effect.
"But the taste difference may be explained by differences like parental control over sweet consumption."

Wednesday, April 22, 2009

Health Nut

Make sure when eating walnuts you are using about one-fourth cup as a serving and that they are raw; organic nuts are always the best choice. Too many, however, can possibly suppress thyroid function.

Walnuts contain an antioxidant compound called ellagic acid that supports the immune system and appears to have several anticancer properties.

More about walnuts

Nutritional Data
Walnuts may prevent breast cancer
Eating walnuts may help to reduce the risk of developing breast cancer, research suggests.

The nuts contain ingredients such as omega-3 fatty acids, antioxidants and phytosterols that may all reduce the risk of the disease.

Mice fed the human equivalent of two ounces (56.7g) of walnuts per day developed fewer and smaller tumours.

The US study was presented to the American Association for Cancer Research annual meeting.

“ We know that a healthy balanced diet - rich in fruit and vegetables - plays an important part in reducing the risk of many types of cancer ”
Josephine Querido Cancer Research UK


Researcher Dr Elaine Hardman, of Marshall University School of Medicine, said although the study was carried out in mice, the beneficial effect of walnuts was likely to apply to humans too.

She said: "We know that a healthy diet overall prevents all manner of chronic diseases."

"It is clear that walnuts contribute to a healthy diet that can reduce breast cancer."

Previous research has suggested eating walnuts at the end of a meal may help cut the damage that fatty food can do to the arteries.

It is thought that the nuts are rich in compounds that reduce hardening of the arteries, and keep them flexible.

In the latest study mice were either fed a standard diet, or the walnut-based diet.

The animals fed walnuts developed fewer tumours, and those that did arise took longer to develop and were smaller.

Molecular analysis showed that omega-3 fatty acids played a key role - but other parts of the walnut contributed as well.

Nutritional value

Anna Denny, a nutrition scientist at the British Nutrition Foundation, said evidence for nuts reducing the risk of heart disease was currently stronger than it was for their anti-cancer properties.

She said: "Although nuts are high in fat (and thus calories), the fatty acids in nuts are predominantly 'good' unsaturated fatty acids.

"Other additional components of nuts that may contribute to a reduction in heart disease and cancer risk include fibre and 'bioactive' compounds.

"Among the many bioactive compounds found in nuts are phytosterols and flavonoids.

"More research is needed before it will be possible to attribute specific health benefits of nuts to specific bioactive compounds because nuts contain a complex mixture of different bioactive compounds."

Josephine Querido, of the charity Cancer Research UK said there was insufficient evidence to show that eating walnuts could prevent breast cancer in humans.

She said: "We know that a healthy balanced diet - rich in fruit and vegetables - plays an important part in reducing the risk of many types of cancer.

"The strongest risk factor for breast cancer is age - 80% of breast cancers occur in women over the age of 50 so attending screening is important.

"Making lifestyle changes, such as keeping a healthy body weight, limiting alcohol intake and taking regular exercise, can also help reduce breast cancer risk."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/8009647.stm
Published: 2009/04/22 00:47:06 GMT © BBC MMIX

Monday, March 23, 2009

The Tuna Calculator

Here's a handy little tool that will tell you how much tuna fish you can eat safely.

Thursday, March 12, 2009

Cancer: A Nutritional and Environmental Dis-Ease

This last sentence from the following story tells it all.
"One theory is that the change in caloric intake beefs up cell repair mechanisms against destructive agents called free radicals."

Since 1962 we have been told that cancer is a nutritional disease. Now we have the added and cumulative effect of environment, including vaccines. Even veterinarians are relating cancer in companion animals to the vaccines.

The use of the term "free radicals" also tells you that there is a very real reason why sound nutrition and vitamins are helpful in the process of recovering from cancer.

Articles like this make me wonder if any of the so called researchers know what they are doing, or even what they are saying.

If I look at just one cancer drug, 5 FU, a fluoride based long used chemo drug, I find that it depletes these nutrients -

NB:Limited test tube research occasionally does support the idea that an antioxidant can interfere with oxidative damage to cancer cells. However, most scientific research does not support this supposition.

Antioxidants*

Multiple nutrients* (malabsorption)
Taurine* reduces the likelihood and/or severity of a potential side effect caused by the medication.
Beta-carotene* (mouth sores)
Chamomile* (mouth sores)
Eleuthero* (Eleuthero (Eleutherococcus senticosus)
Russian research has looked at using eleuthero with chemotherapy. One study of patients with melanoma found that chemotherapy was less toxic when eleuthero was given simultaneously. Similarly, women with inoperable breast cancer given eleuthero were reported to tolerate more chemotherapy.45 Eleuthero treatment was also associated with improved immune function in women with breast cancer treated with chemotherapy and radiation.)
Ginger* (nausea)
Glutamine* (mouth sores)(intestinal toxicity)
Melatonin
N-acetyl cysteine* (NAC)
Probiotics (Lactobacillus GG)
Spleen peptide extract* (see text)
Thymus peptides* (see text)
Vitamin B6
Vitamin E*, topical (mouth sores)(also prevents hair loss)
Milk thistle*
PSK* (Coriolus versicolor)- The mushroom Coriolus versicolor contains an immune-stimulating substance called polysaccharide krestin, or PSK. PSK has been shown in several studies to help cancer patients undergoing chemotherapy. One study involved women with estrogen receptor-negative breast cancer. PSK combined with chemotherapy significantly prolonged survival time compared with chemotherapy alone. Another study followed women with breast cancer who were given chemotherapy with or without PSK. The PSK-plus-chemotherapy group had a 25% better chance of survival after ten years compared with those taking chemotherapy without PSK. Another study investigated people who had surgically removed colon cancer. They were given chemotherapy with or without PSK. Those given PSK had a longer disease-free period and longer survival time. Three grams of PSK were taken orally each day in these studies.)
New clue on why cancer spread is linked to diet Mar 11, 2009
PARIS (AFP) – Investigators on Wednesday said there could be a clue to explain why dietary restriction succeeds or fails in braking the growth of cancer.

Scientists spotted a century ago the link between calorie intake and the progression of certain kinds of tumour.

But how this works at the molecular level has been unclear. In addition, tumours may remain puzzlingly immune to fasting among some individuals but not among others, which is partly why the practice has not been incorporated into cancer treatment.

Nada Kalaany and David Sabatini of the Massachusetts Institute of Technology (MIT) looked at the impact of food curbs on six types of human cancers that had been grafted onto mice which had been genetically modified to lack immune resistance.

The mice were then split into two groups, with one batch able to tuck into a standard rodent diet for two to three weeks. The others received daily meals that amounted to a 40 percent reduction in calories compared to their counterparts, which led to a fall of between 20 and 30 percent in body weight.

The researchers conclude that tumours' sensitivity to fasting depends on a key pathway -- activation of an enzyme called phosphatidylinositol-3-kinase, also called PI3K, which plays an important role in the proliferation of cancer cells.

If the PI3K pathway is closed, tumours respond to dietary restriction, and vice versa.

The study is important because it helps drug designers who are working hard on prototype treatments that mimic the effects of dietary curbs on cancer.

As several cancer types carry mutations that could cause the PI3K mechanism to open up, the paper suggests that the approach will not work in certain cases.

The paper is published by the British-based journal Nature.

Previous research on lab rodents suggests that a calorie decrease of 10 to 50 percent leads to a reduction in the incidence of certain cancers and brakes the speed at which they spread.

One theory is that the change in caloric intake beefs up cell repair mechanisms against destructive agents called free radicals.

Wednesday, February 11, 2009

Eggs Now an Approved Food

UPDATE: 17 August, 2010 - How Hens are Confined

Eggs have always been a health promoting food, except that somewhere along the line some diet dictocrat decided they were not heart health because they contained cholesterol.

This false notion led to those egg white products loaded with food processing chemicals to enhance shelf live and preserve the products in fluoride containing polyfilm lined paper boxes.

Its a wonder all this took so long to get out in the news. Here is an earlier story from 2001 supporting eggs for health.

And another piece on the health promoting lecithin in egg yolk. Lecithin helps keep your arteries free of plaque and in good shape.

My preference is for organic, free-range brown eggs. Brown eggs have higher sulfur content and that's another health plus.
Regular eggs 'no harm to health'
Limiting egg consumption has little effect on cholesterol levels, research has confirmed.

A University of Surrey team said their work suggested most people could eat as many eggs as they wanted without damaging their health.

The researchers, who analysed several studies of egg nutrition, said the idea that eating more than three eggs a week was bad for you was still widespread.

But they said that was a misconception based on out-of-date evidence.

Writing in the British Nutrition Foundation's Nutrition Bulletin, they said eating saturated fats was far more likely to cause health problems.
Researcher Professor Bruce Griffin said eggs were actually a key part of a healthy diet, as they were particularly packed full of nutrients.


Ingrained misconception

He said: "The ingrained misconception linking egg consumption to high blood cholesterol and heart disease must be corrected.

"The amount of saturated fat in our diet exerts an effect on blood cholesterol that is several times greater than the relatively small amounts of dietary cholesterol.

"The UK public do not need to be limiting the number of eggs they eat - indeed they can be encouraged to include them in a healthy diet as they are one of nature's most nutritionally dense foods."

While elevated blood cholesterol levels increase the risk of heart disease, only around a third of the cholesterol in the body comes from the diet.

Other factors such as smoking, being overweight and physical activity can influence blood fat and cholesterol levels and heart disease risk.

The British Heart Foundation (BHF) dropped its advice to limit egg consumption to three a week in 2007 in light of new evidence.

However, research by the British Egg Information Service suggests 45% of consumers still believe it was sensible to limit consumption.

Victoria Taylor, a senior BHF dietician, said: "We recommend that eggs can be eaten as part of a balanced diet.

"There is cholesterol present in eggs but this does not usually make a great contribution to your level of blood cholesterol.

"If you need to reduce your cholesterol level it is more important that you cut down on the amount of saturated fat in your diet from foods like fatty meat, full fat dairy products and cakes, biscuits and pastries."

In 2007 the Egg Information Service was banned from re-running a television commercial from the 1950s which urged viewers to "go to work on an egg" to celebrate its 50th anniversary.

The Broadcast Advertising Clearance Centre said the slogan went against the principle of eating a varied diet.

Story from BBC NEWS:http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/7882850.stm
Published: 2009/02/11 © BBC MMIX

Friday, January 16, 2009

Postnatal depression prevented with counselling

I suppose that Brooke Shields found it much easier to take a pill that may have deleterious effects on her health rather than look at her nutritional status and food plan, when she has had to face depression after child birth.

I suppose Tom Cruise might find this article enlightening in light of his more natural approach to health in pregnancy.

Tom has an edge when he sides for nutritional supplements, but coupled with counselling, things might have just gotten a lot easier for mothers-in-waiting.

Maybe US obstetricians need to update their thinking too.
Postnatal depression can be treated, prevented
Thu Jan 15, 2009
PARIS (AFP) – Many women struggling with the post-baby blues may expect only a hug or a couple of pills, but in new studies published on Friday, doctors say counselling can not only treat this risky condition but prevent it, too.

Professional counsellors can reduce rates of postnatal depression by 40 percent, while support from fellow mothers can reduce the risk of developing this dangerous disorder by half, they say.

In one paper, a team led by Jane Morrell of the University of Sheffield, northern England, divided more than 4,000 new mothers into three groups.

In the first two groups, the volunteers each received a weekly session of psychological counselling over eight weeks, using either of two techniques.

The so-called "cognitive behaviour approach" focuses on unhelpful behaviour patterns and thoughts in the mother, and helps overcome them by pointing out that these reflexes are a common part of the post-natal experience.

The "person-centered approach" emphasizes empathy and unconditional support for the mother's feelings.

The third group was a "control" group of women who received standard health care treatment.

Women who were diagnosed with depression six weeks after giving birth were 40 percent less likely to have the same symptoms six months later if they had either form of counselling, the investigators found.

The second trial, likewise published in the British Medical Journal (BMJ), identified 701 pregnant women in Ontario, Canada, who were estimated to be at risk of developing postnatal depression.

Half of the group were given standard post-natal care while the other half were given telephone support by a peer volunteer -- a woman with first-hand knowledge of post-baby blues.

Getting this peer support halved the risk of depression at 12 weeks after birth, the report said.

"These trials add to the growing evidence that postnatal depression can be effectively treated and possibly prevented," said lead researcher Cindy-Lee Dennis of the University of Toronto.

The barriers to treatment, however, remain high, she said.

Women are often unaware of the syndrome and are apt to deny or minimise its symptoms. And even when they do feel they need help, they may be unaware of treatment options or unwilling to reveal emotional distress.

"They fear being labelled mentally ill, having their children taken away, or being perceived as not fulfilling their maternal role," she said.

Postnatal depression affects one in eight women in diverse cultures around the world, and is one of the leading causes of maternal mortality, usually through suicide.

The generally short-term but devastating mental disorder can also have a serious impact on infants and children, affecting cognitive, emotional and social development.

Copyright © 2009 Agence France Presse. All rights reserved.

Monday, November 24, 2008

Natural Perspective on Gardasil

Sweden now will provide this vaccine free of charge. Perhaps they have over looked the facts and other risks.
Gardasil is a vaccination against human papillomavirus (HPV) that’s manufactured by Merck & Co. and marketed as “anti-cancer.” However, Canada has one of the lowest cervical cancer rates in the world.

In addition, 70 percent of women with HPV infection clear it spontaneously within one year, and 90 percent within two years.

This means that even if a woman has a high-risk strain of HPV, there is a very good likelihood that her immune system will be able to resolve it naturally.

The risk of any cervical disease is greatly decreased with a yearly Pap smear and safe sexual practices. There is a concern that this vaccine will give women a false sense of security and decrease yearly Paps and safe sexual practices.
Other factors that increase the risk of cervical cancers include:
long-term oral contraceptive use,
poverty,
stress,
smoking
and nutritional deficiencies.

Addressing these factors, irrespective of vaccination, is very important.

Thursday, November 13, 2008

And Now for the Rest of the Story

Just this past Sunday (9 November, 2008) I posted this article on Natural Health News: Boosting Drug Sales with Studies.

I added one follow-up article earlier today, and now I am happy to give you something to think about in terms of why sound nutrition is a better option than wholesale use of drugs. Supplements certainly do edge out the pharmaceuticals in this study.

You'll also see how it is totally possible to fool a lot of the people a lot of the time -
Why treat nutritional deficiency with drugs?
(OMNS, November 13, 2008) A recent study suggested that statins might be used to avoid the effects of nutritional deficiency. Writing in the New England Journal of Medicine, the Jupiter group described a study of statin drugs in people with high C-reactive protein and low cholesterol. (1) High C-reactive protein levels are associated with inflammation and heart disease/stroke. The authors concluded that, in apparently healthy persons with elevated C-reactive protein levels, rosuvastatin (Crestor) significantly reduced the incidence of major cardiovascular events.

Their much-publicized claim, that this statin lowers the risk of heart attack by approximately one half, is technically correct though highly misleading. The reported annual incidence of coronary events was 37 people in 10,000 (controls) and 17 people in 10,000 (treated). Similar results were reported for risk of stroke. When expressed as a proportion, a 46% improvement (17/37) sounds large. However, an improvement of 20 events (37-17) in 10,000 people known to be at risk is less impressive. Such an improvement means that 500 people (10,000/20) with this increased risk would need to take the tablet daily for a year, to prevent one person suffering an event.

The paper does not explicitly report deaths. One reason for this may be that if a person on statins suffered a heart attack, that person was about three times more likely to die than a control who was not on statins.

The cost of rosuvastatin per person is approximately $1000 per year. So, treating enough people to prevent one heart attack costs $500,000 per year. Since about 70% of the heart attacks were not fatal, prevention of a single death from heart attack would cost even more, approximately $1,700,000. Giving the benefit of the doubt, we may allow for a similar reduction in stroke and say that "only" $250,000 is needed to protect one person from a stroke or heart attack. It is hardly surprising that Astra Zeneca's share price increased by $1.3 billion dollars on release of this paper and the corresponding media hype. (2)

The media suggested millions of healthy people could cut their risk of heart disease by taking statins. (3) They also claimed that statins could cut the risk of heart attack for "everyone". (4) This is inaccurate and incorrect. The study did not include normal healthy people, only a sample of a relatively small number of people, suffering from inflammation (increased C-reactive protein) - a known cause of heart disease and stroke. Out of 89,890 people considered for inclusion, 17,802 people (19.8%) met the specific criteria of poor health for the study. Widespread prescription of statins to healthy people is not supported by these findings.

The fact that statins produce a modest improvement is unsurprising, since they are known to lower inflammation, as do many nutritional supplements. It has pointed out that Crestor lowered C-reactive protein by 37%, but vitamin E lowers it (C Reactive Protein) by 32%, (5) and vitamin C by 25.3%. (6,7) These effects are similar to those of statins and would be expected to provide comparable benefits, without side effects and at a lower cost.

Crestor and other statin drugs have serious side effects. The incidence of established side-effects, such as rhabdomyolysis (0.3 per 10,000 per year), myopathy (1.1 per 10,000) and peripheral neuropathy (1.2 per 10,000 per year) seems low, (8) but may be underestimated as it takes time to establish long-term side-effects. (The depletion of coenzyme Q10 by statins is a particular concern.) The figures imply that for every ten people who avoid a cardiovascular event, at least one previously healthy person will suffer a non-trivial side effect of the statin drug.

The doctors reported a statistically significant increase (270) in diabetes in the statin group compared to the placebo group (216). Over the course of the study, this corresponds to an increased risk of approximately 61 in 10,000 people. So, the number of people on statins reported to become diabetic was greater than the number that avoided a heart attack! These people might have shorter lives and be at greater risk of heart disease in the long term.

Notably, the Jupiter study was stopped early, which the authors admit prevents assessment of how side-effects might outweigh reported benefits in the longer term. The study was to last 3-5 years and the criteria for stopping were not included in the original published design. (9) The paper claims that when the study was stopped "these [diabetic] events were not adjudicated by the end-point committee". The committee either knew about the diabetes in which case it was considered, or it did not and the committee was not doing its job properly.

The Jupiter name stands for Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; the reader might think this "justification" sounds more like a marketing plan than a scientific endeavor. The researchers did not address the underlying cause of the inflammation and increased C-reactive protein: they simply treated the condition with drugs. In many cases, raised C-reactive protein is a result of nutritional deficiency. (10)

It is worth mentioning that several nutritional supplements inhibit inflammation and lower C-reactive protein, without causing known side effects. Deficiency in vitamins A, (11) B6, C, E, A, folate, carotenoids and lycopene, (12) and selenium (for example) is associated with raised C-reactive protein. (13,14,15) We suggest that the $250,000 cost of preventing a single cardiovascular event with rosuvastatin might be better spent funding a study of such inexpensive alternatives the deficiency of which may be the cause of the problem.

The people at risk could be encouraged to supplement their diet and restore their health without using these expensive drugs to conceal their underlying sickness.

Stick with the supplements!

References:

(1) Ridker P.M. Danielson E. Fonseca F.A.H. Genest J. Gotto A.M. Kastelein J.J.P. Koenig W. Libby P. Lorenzatti A.J. MacFadyen J.G. Nordestgaard B.G. Shepherd J. Willerson J.T. Glynn R.J. for the JUPITER Study Group (2008) Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein, NEJM, 359(21), 2195-2207.

(2) Mail Online (2008) Crestor news helps AstraZeneca market value leap by more than £1.3bn, 9:25 PM, 10th Nov.

(3) Smith R. (2008) Millions could cut heart attack risk by taking statins, study finds, telegraph.co.uk, 7:55AM GMT, 10 Nov.

(4) Hope J. (2008) The new statin drug that cuts the risk of heart attacks and strokes for EVERYONE, Daily Mail, 11th Nov.

(5) Devaraj S. Tang R. Adams-Huet B. Harris A. Seenivasan T. de Lemos J.A. Jialal I. (2007) Effect of high-dose alpha-tocopherol supplementation on biomarkers of oxidative stress and inflammation and carotid atherosclerosis in patients with coronary artery disease, Am J Clin Nutr, 86(5), 1392-1398.

(6) Block G. Jensen C.D. Dalvi T.B. Norkus E.P. Hudes M. Crawford P.B. Holland N. Fung E.B. Schumacher L. Harmatz P. (2008) Vitamin C treatment reduces elevated C-reactive protein, Free Radic Biol Med, Oct 10. [Epub]

(7) Sardi B. (2008) The Headline You Should Be Reading: Statin Drugs Don't Save Lives And May Increase Your Risk For Diabetes, Knowledge of Health Report, Nov 11.

(8) Law M. Rudnicka A.R. Statin Safety: A Systematic Review, The American Journal of Cardiology, 97(8), Suppl 1, S52-S60.

(9) Ridker P.M. JUPITER Study Group (2003) Rosuvastatin in the primary prevention of cardiovascular disease among patients with low levels of low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: rationale and design of the JUPITER trial, Circulation, 108(19), 2292-2297.

(10) Ford E.S. Liu S. Mannino D.M. Giles W.H. Smith S.J. (2003) C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults, European Journal of Clinical Nutrition, 57, 1157-1163.

(11) Root M.M. Hu J. Stephenson L.S. Parker R.S. Campbell T.C. (1999) Determinants of plasma retinol concentrations of middle-aged women in rural China. Nutrition 15, 101-107.

(12) Boosalis M.G. Snowdon D.A. Tully C.L. Gross M.D. (1996): Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study, Nutrition, 12, 475-478.

(13) Friso S. Jacques P.F. Wilson P.W. Rosenberg I.H. Selhub J.(2001) Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels, Circulation, 103(23), 2788-2791.

(14) Devaraja S. Jialal I. (2000) Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients, Free Radical Biology and Medicine, 29(8), 790-792.

(15) Upritchard J.E. Sutherland W.H. Mann J.I. (2000): Effect of supplementation with tomato juice, vitamin E, and vitamin C on LDL oxidation and products of inflammatory activity in type 2 diabetes, Diabetes Care, 23, 733-738.

Nutritional Medicine is Orthomolecular Medicine

Tuesday, November 11, 2008

Fertility Concerns

Several new reports show that the effect of supplements can be very helpful when conception and fertility are concerned.

Read the new news notes...

And do remember that your nutritional status has a great impact on your health, especially when planning for a baby.

Low Magnesium, High Blood Pressure

While the original purpose for ADVENTURX was to prevent arm pump in xtreme sports many other benefits have been found during the four years my formula has been available.

Most of us who study natural healing and nutrition already know how magnesium helps reduce blood pressure. Magnesium is nature's ACE inhibitor.

The added benefit of oxygen producing elements in ADVENTURX may be helpful to the process of lowering blood pressure as well.
Evidence that increased reactive oxygen species are link between magnesium deficiency and hypertension
The relationship between high blood pressure and magnesium deficiency has been explored in several studies, producing conflicting evidence. A study published in the November 2002 issue of the Journal of Hypertension submits the hypothesis that insufficient levels of magnesium may lead to hypertension by increasing the formation of reactive oxygen species, harmful molecules that cause oxidative damage.

The University of Montreal researchers divided stroke-prone spontaneously hypertensive rats into three groups that received a control diet containing normal levels of magnesium, a magnesium-free diet and a high magnesium diet, and systolic blood pressure was measured each week for sixteen weeks. In a second experiment, stroke-prone spontaneously hypertensive rats received a control diet, a magnesium-free diet and a magnesium-free diet combined with Tempol, a superoxide dismutase mimetic for seven weeks. Superoxide dismutase is one of the antioxidants naturally produced in the body.

Rats in the low magnesium group experienced an exacerbation in the development of hypertension after five weeks, accompanied by a reduction in oxidative stress markers which increased rapidly after two weeks. The ability of blood vessels to dilate in response to acetylcholine was decreased in the low magnesium group compared to controls. Vessel wall hypertrophy was greater and vascular superoxide higher in the rats who received the magnesium deficient diet compared to those on the high magnesium diet. However, rats on magnesium-free diets receiving Tempol did not experience a progression of hypertension or the vascular changes seen in magnesium deficient rats who did not receive the antioxidant.

In an accompanying editorial, Richard D Bukoski writes that the research provides, "the first link between an essential dietary nutrient and the key molecular pathways involved in regulating vascular smooth muscle growth and structure." (Journal of Hypertension 2002, 20:2141-2143)

Sunday, November 9, 2008

Boosting Drug Sales with Studies

For quite a number of years many health professionals have been speaking out against the statin class of drugs.

Much of the concern is associated kidney failure secondary to muscle wasting. Other serious effects have been noted, yet the drug giants keep coming up with ways to try to convince absolutely everyone they need to be taking these drugs.

Now even the "healthy".

One of the key investigators busting this myth has been Uffe Ravnskov, MD

And what ever happened to improving health with foods and supplements to reduce or eliminate this problem.

Recall that the homogenization of milk (and lack of access to raw milk) really kicked off the march to atherosclerosis back in the 1950s.

And remember that lecithin or eating plain applesauce mixed in plain yoghurt aids healthy, clean and flexible arteries. And with major cost savings over these drugs.

Other issues are the fact that many of the statin drugs are fluoride based, such as Baychol - now off the market.

Even Red Rice Yeast can have the same side effects of the drugs.

Statins and the problems associated with their use is the result of marketing a class of drugs before it was fully investigated.

The imprecise use of statin medications is one big reason why side effects occur in more than 40 percent of patients and why 60-75 percent of statin users discontinue treatment.

Crestor averages about $2 a pill, with a range from $1.41 to $3.41 at a variety of pharmacies. The drug company profit for these drugs is in the 4000 percent range. If you get 10 mg of Crestor when you only need 1 mg, risks increase drastically. With each doubling of a statin dosage, the risk of liver injury also doubles.

Concerned about the renal effects of Crestor, some people have been openly weighing the options between taking a statin or accepting a higher cholesterol number. (For instance, is high cholesterol "normal"? Have we fallen victim to high-end marketing tactics?)

All the statin drugs can cause rhabdomyolysis and kidney failure. In most cases the kidney failure is secondary to blocking of the tiny kidney tubules by the breakdown fragments of muscle cells. The mechanism of action here is loss of cell wall integrity of the muscle cells due to interference of the statin drugs with the vital role of ubiquinone in our bodies.

Ubiquinone, known also as Co-enzyme Q10, is collaterally damaged during the statin drug effect on the so- called mevalonate pathway of cholesterol biosynthesis. Ubiquinone metabolism is a branch on the mevalonate "tree" inevitably damaged by these statin drug "reductase inhibitor" action and the stronger the statin, the more severe this effect.

Public Citizen filed a Citizen's Petition with the FDA suggesting that Crestor be removed from the market. Though the courts did not pass a judgement in favor of Public Citizen (thus allowing Crestor to remain a legally prescribed medication), the case brought to light the fact that statins like Crestor can and do cause serious problems in many patients who take them.

In May of 2005, a study published in the American Heart Association's journal, Circulation, revealed that kidney problems and muscle weakness were two to eight times more frequent among Crestor users than those taking other cholesterol-lowering drugs.

Read more

more

and more
Study: Wider cholesterol drug use may save lives
By MARILYNN MARCHIONE, AP Medical Writer Marilynn Marchione, Ap Medical Writer
Sun Nov 9, 9:44 am ET

NEW ORLEANS – People with low cholesterol and no big risk for heart disease dramatically lowered their chances of dying or having a heart attack if they took the cholesterol pill Crestor, a large study found.

The results, reported Sunday at an American Heart Association conference, were hailed as a watershed event in heart disease prevention. Doctors said the study might lead as many as 7 million more Americans to consider taking cholesterol-lowering statin drugs, sold as Crestor, Lipitor, Zocor or in generic form.

"This takes prevention to a whole new level, because it applies to patients who we now wouldn't have any evidence to treat," said Dr. W. Douglas Weaver, a Detroit cardiologist and president of the American College of Cardiology.

The study also gives the best evidence yet for using a new test to identify people who may need treatment, according to a statement from Dr. Elizabeth Nabel, director of the National Heart, Lung and Blood Institute. The new research will be considered by experts reviewing current guidelines.

However, some doctors urged caution. Crestor gave clear benefit in the study, but so few heart attacks and deaths occurred among these low-risk people that treating everyone like them in the United States could cost up to $9 billion a year — "a difficult sell," one expert said.

About 120 people would have to take Crestor for two years to prevent a single heart attack, stroke or death, said Stanford University cardiologist Dr. Mark Hlatky. He wrote an editorial accompanying the study published online by the New England Journal of Medicine.

"Everybody likes the idea of prevention. We need to slow down and ask how many people are we going to be treating with drugs for the rest of their lives to prevent heart disease, versus a lot of other things we're not doing" to improve health, Hlatky said.

Statins are the world's top-selling drugs. Until this study, all but Crestor have already been shown to cut the risk of heart attacks and death in people with high LDL, or bad cholesterol.

But half of all heart attacks occur in people with normal or low cholesterol, so doctors have been testing other ways to predict who is at risk.

One is high-sensitivity C-reactive protein, or CRP for short. It is a measure of inflammation, which can mean clogged arteries as well as less serious problems, such as an infection or injury. Doctors check CRP with a blood test that costs about $80 to have done.

A co-inventor on a patent of the test, Dr. Paul Ridker of Harvard-affiliated Brigham and Women's Hospital in Boston, led the new study. It involved 17,802 people with high CRP and low LDL cholesterol (below 130) in the U.S. and 25 other countries.

One-fourth were black or Hispanic, and 40 percent were women — important because previous statin studies have included few women. Men had to be 50 or older; women, 60 or older. None had a history of heart problems or diabetes.

They were randomly assigned to take dummy pills or Crestor, the strongest statin on the market, made by British-based AstraZeneca PLC. Neither participants nor their doctors knew who was taking what.

The study was supposed to last five years but was stopped in March, after about two years, when independent monitors saw that those taking Crestor were faring better than the others.

Full results were announced Sunday. Crestor reduced a combined measure — heart attacks, strokes, heart-related deaths or hospitalizations, or the need for an artery-opening procedure — by 44 percent.

"We reduced the risk of a heart attack by 54 percent, the risk of a stroke by 48 percent and the chance of needing bypass surgery or angioplasty by 46 percent," Ridker said.

Looked at another way, there were 136 heart-related problems per year for every 10,000 people taking dummy pills versus 77 for those on Crestor.

Remarkably, every single subgroup benefited from the drug.

"If you're skinny it worked, if you're heavy it worked. If you lived here or there, if you smoked, it worked," Ridker said.

AstraZeneca paid for the study, and Ridker and other authors have consulted for the company and other statin makers.

One concern: More people in the Crestor group saw blood-sugar levels rise or were newly diagnosed with diabetes.

Crestor also has the highest rate among statins of a rare but serious muscle problem, so there are probably safer and cheaper ways to get the same benefits, said Dr. Sidney Wolfe of the consumer group Public Citizen.

"It is highly unlikely that (the benefits are) specific to Crestor," said Wolfe, who has campaigned against the drug in the past.

Crestor costs $3.45 a day versus less than a dollar for generic drugs.

Drs. James Stein and Jon Keevil of the University of Wisconsin-Madison used federal health statistics to project that 7.4 million Americans, or more than 4 percent of the adult population, are like the people in this study.

Treating them all with Crestor would cost $9 billion a year and prevent about 30,000 heart attacks, strokes or deaths, they calculate.

"That's pretty costly. This would be a very difficult sell" unless a person also had family history or other heart disease risk factors, said Dr. Thomas Pearson of the University of Rochester School of Medicine and Dentistry.

Pearson was co-chairman of a joint government-heart association panel that wrote current guidelines for using CRP tests to guide treatment.

Researchers do not know whether the benefits seen in the study were due to reducing CRP or cholesterol, since Crestor did both.

This study and two other government-sponsored ones reported on Sunday "provide the strongest evidence to date" for testing C-reactive protein, and adding it to traditional risk measures could identify millions more people who would benefit from treatment, Nabel's statement says.

U.S. Crestor prescriptions totaled $420 million in the third quarter of this year, up 23 percent from a year earlier. In the rest of the world, third quarter sales were $520 million, up 33 percent.

Sales have been rising even though two statins — Zocor and Pravachol — are now available in generic form.

On the Net:
New England Journal: http://www.nejm.org
Heart conference: http://www.americanheart.org
Government: http://www.nhlbi.nih.gov/health/dci/Diseases/Cad/CAD_WhatIs.html

 
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