Increased use of 'last resort' antibiotics in Mainstream Medicine

8 April - Related articles:

Alabama bacteria outbreak linked to laboratory
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US in deadly hospital germ probe
Health officials have linked an outbreak of bacterial infection found in nine Alabama hospital patients who died to contamination at a laboratory. SOURCE

Misuse of antibiotics has led to a global health threat: the rise of dangerous—or even fatal—superbugs. Methicillin-resistant Staphylococcus aureus (MRSA) is now attacking both patients in hospitals and also in the community and a deadly new multi-drug resistant bacteria called carbapenem-resistant Klebsiella pneumoniae, or CRKP is now in the headlines. Last year, antibiotic resistant infections killed 25,000 people in Europe, the Guardian reports.

7 April - Related articles:

While the use of theses drugs increase, little seems to be happening to address the core issues of the problem of antibiotic resistance. This does not appear to show us that newer and more creative ideas are even considered.

Chinese ministry, WHO warn of antibiotic overuse
http://news.yahoo.com/s/ap/20110407/ap_on_he_me/as_china_antibiotics

Europe Losing Super Bug Battle http://www.bbc.co.uk/news/health-12975693

Such has happened to the protocol I developed in 1993.

DALLAS, April 6 (UPI) -- A study of Veterans Administration's acute care facilities indicates increased use of carbapenems, a powerful class of antibiotics, U.S. researchers say.

Dr. Makoto Jones and colleagues used barcode medication administration data for antibiotics administered in 110 VA acute care facilities from 2005 to 2009.

In the five-year study period, there was a gradual increase in overall antibiotic use and a 102 percent increase in the use of carbapenems -- a powerful class of "last resort" antibiotics. The study found a 79 percent increase in the use of intravenous vancomycin and 41 percent increase combinations of penicillin with beta-lactamase-inhibitors. A 20 percent increase in fluoroquinolones* were the most frequently used drugs across facilities.

Additionally, the researchers noted the quantity of antibiotics reported from VA facilities seems similar to reported data from non-VA hospitals in the United States.

"Use of these antibiotics helps the patient receiving the treatment, but has future consequences for innocent bystanders," Jones says in a statement.

"The more these drugs are used, the more resistance we see."

The study was presented at the annual meeting of the Society for Healthcare Epidemiology of America in Dallas.
© 2011 United Press International, Inc. All Rights Reserved.

Read more: http://www.upi.com/Health_News/2011/04/06/Increased-use-of-last-resort-antibiotics/UPI-98881302098169/print/#ixzz1Ill52RuQ

On a similar topic of increased use of drugs at the VA and in civilian medicine, this is worth your consideration as well -

University of Pennsylvania School of Medicine (2011, April 5). Opioids now most prescribed class of medications in America. ScienceDaily. Retrieved April 6, 2011, from http://www.sciencedaily.com/releases/2011/04/110405161906.htm  

My Note: fluoroquinolones*  Fluoride based antibiotic compounds, cause tendon rupture often.

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Posted in: antibiotics,first natural health news,first natural news,natural health news,opioids,VA

Regenerating Brain Cells

When I worked in the Neuro ICU in the early 1970s I was teased relentlessly at times by doctors who believed I was a bit wacky when I'd argue for the ability of the human body to regenerate brain and nerve cells.

The 1990s found me happy when I read a report on a similar result in a study.

Now it seems we are making more headway, and the jokes can stop.

I've applied a process to accomplish this with people who have had traumatic brain injury and suffer with PTSD. I'm sure it applies to the current situation with our young soldiers.

Scientists coax brain cells in mice to regenerateBy Julie Steenhuysen
Thu Nov 6, 2008

CHICAGO (Reuters) – Scientists have found a way to get damaged nerve cells in the brains of mice to repair themselves, a finding that may lead to new treatments for spinal cord and brain injuries.

By turning off proteins that keep nerve cell growth in check, the researchers were able to stimulate regrowth in mice with damaged optic nerves, they reported on Thursday.

"This is the first time it has been possible to see such significant regeneration by manipulating single molecules," Zhigang He of Children's Hospital Boston, whose study appears in the journal Science, said in a statement.

A separate team found that blocking a protein that discourages cell repairs allowed nerve cells in lab dishes to regenerate.

Taken together, the findings offer leads on ways to coax damaged nerves in the brain and spinal cord to fix themselves.

The studies focused on nerve fibers called axons that carry electrical signals throughout the body.

"In your arms and legs, if these fibers are severed, they can regrow back to the muscle," said Marc Tessier-Lavigne, executive vice president of research drug discovery at biotechnology firm Genentech Inc.

"Nerve fibers in the brain and spinal cord do not regenerate. When you have a spinal cord injury, the paralysis is usually permanent," he said in a telephone interview.

"The ambition of our field is to understand why it is the fibers don't regenerate in the central nervous system."

REKINDLING GROWTH

He's team focused on a gene network called the mTOR pathway, which is very active when young nerve cells are first growing but becomes less active once nerve cells mature.

Nerve injury appears to shut down this network completely. And two proteins -- PTEN and TSC1 -- appear to be responsible for silencing this pathway, the researchers discovered.

"If we get rid of (those proteins), axons can regenerate very dramatically," He said in a telephone interview.

Mice genetically engineered to lack the proteins kept more neurons after an injury to the optic nerve than normal mice. And the mutant mice were able to grow new axons within two weeks.

He said the study suggests that blocking the proteins might rekindle the nerve cell's natural ability to grow. The team is now looking for drugs that can block the proteins.

Tessier-Lavigne and colleagues focused on a different problem -- the chemicals in the body that discourage repairs.

"Even if the nerve cell could regrow, the environment is hostile to regrowth," Tessier-Lavigne said.

He said when an axon in the spinal cord is severed, the cut end sprouts a growth cone.

"It almost looks like a little hand at the end of this cable-like structure," he said.

Tiny sensors on the growth cone pick up chemical signals. In nerves in the periphery of the body such as the finger, signals tell the axon to repair itself. But in the central nervous system, chemical signals repress growth.

Tessier-Lavigne's team found one of those signals -- a protein called PirB -- in the insulating myelin sheath that wraps around each neuron. When they blocked this myelin protein in cell cultures, they got nerve cells to grow.

Tessier-Lavigne said the hope is to use this information to make drugs that allow nerve cells in the brain and spine to repair themselves.

(Editing by Maggie Fox and John O'Callaghan) Copyright © 2008 Reuters Limited.

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Posted in: brain cells,health news,natural health news,natural news,PTSD,regeneration,TBI,VA,veterans